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Quote of the day

'By far the greatest danger of Artificial Intelligence is that people conclude too early that they understand it'

 

Eliezer Yudkowsky

Cancer drug reverses Alzheimers in mice

RATE THIS! +0
Posted in Medicine on 11th Feb, 2012 08:07 PM by APM

What a quick turnaround: a drug used to treat cancer can reverse Alzheimer's disease in mice – and it takes just 72 hours to work its magic. It remains to be seen if the drug has the same effect in people with Alzheimer's, though.

 

Alzheimer's disease is associated with deposits of beta-amyloid peptides in the brain. The build-up is thought to underlie the abnormal brain activity that leads to memory problems, and also kick-starts a chemical cascade that ultimately leads to the death of neurons.

 

Paige Cramer at Case Western Reserve University School of Medicine in Cleveland, Ohio, reckoned it might be possible to prevent that build-up using bexarotene, an anti-cancer drug. She reasoned that a healthy brain can clear beta-amyloid deposits through a process facilitated by a substance called apolipoprotein E (ApoE). ApoE is activated in part by a receptor called RXR – and bexarotene enhances the action of RXR.

 

When mice with Alzheimer's-like brain damage were given bexarotene orally, they were able to clear more than half of the beta-amyloid peptides from the brain within 72 hours. They also showed a rapid reversal of cognitive and social deficits.

 

Cramer says she hopes to begin phase 1 clinical trials in the next few months. "We believe that because bexarotene is approved [for use in humans], we will be able to transition much more quickly from basic research to the clinic," she says.

 



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Comments

Author: Guest
Posted: 2012-07-30
+0
The song is a total let down. I wasn't a huge fan of Resonant Blue either, but I could at least see how polepe could like it. This song is just white noise, at best, and irritating at worst. I've come to the conclusion the Japanese or H!P or UFwhatever are incredibly stubborn. They get an idea in their head and it doesn't matter if it isn't what polepe want or if it's just not working out they just keep running with it. The pseudo-R&B/Eurotrashified MM is about as entertaining as "serious" Aya Matsuura. I feel like there are sincerely entertaining girls within MM that deserve better, and the MM name itself deserves better. Make MM fun again christ. Reply
Author: Guest
Posted: 2013-10-26
+0
ZFlnQd Thank you ever so for you post.Really looking forward to read more. Keep writing. Reply
Author: Guest
Posted: 2016-12-26
+0
19 juin 2012Your style is so unique in comparison to other people I’ve read stuff from. Thank you for posting when yo#&v8217;ue got the opportunity, Guess I’ll just book mark this web site.   Reply


 

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