Social Media Sidebar

Announcement

Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

We are all now connected by the Internet, like neurons in a giant brain.

 

Stephen Hawking

 

'Nanobombs' that blow up cancer cells

RATE THIS! +32
Posted in Science on 9th Dec, 2015 06:53 PM by AlexMuller
Research have created nanoparticle “Nanobombs” that may be able to kill cancer cells outright, or at least stall their growth, overcoming a biological barrier that has blocked development of drug agents that attempt to alter cancer-cell gene expression. These kinds of drug agents are generally forms of RNA, and are notoriously difficult to use as drugs for two main reasons:
 
They are quickly degraded when free in the bloodstream. When ordinary nanoparticles are taken up by cancer cells, the cancer cells often enclose them in small compartments called endosomes, preventing the drug molecules from reaching their target, and degrading them.
 
In this new study, the researchers packaged nanoparticles with the RNA agent (drug) and ammonium bicarbonate, causing the nanoparticles to swell (as it does in baking bread) three times or more in size when exposed to the heat generated by near-infrared laser light. That causes the endosomes to burst, dispersing the therapeutic RNA drug into the cell.
 
For their study, the researchers used human prostate cancer cells and tumors in an animal model. The nanoparticles were equipped to target cancer-stem-like cells (CSCs), which are cancer cells with properties of stem cells. CSCs often resist therapy and are thought to play an important role in cancer development and recurrence.
 
The therapeutic agent in the nanoparticles was a form of microRNA called miR-34a. The researchers chose this molecule because it can lower the levels of a protein (CD44) that is crucial for CSC survival.
 
Near-infrared light can penetrate tissue to a depth of one centimeter or more, depending on laser-light wavelength and power (see “‘Golden window’ wavelength range for optimal deep-brain near-infrared imaging determined”). For deeper tumors, the light would be delivered using minimally invasive surgery.

Tags: cancercellsoncologynanotechnologyresearchmedicine

Read original article » Back to category

Comments

Author: Guest
Posted: 2015-12-10
+0
Quite a sophisticated cancer weapon. It remains to be seen how this develops in further preclinical studies and whether and how soon it enters clinical trials Reply


 

Recent headlines

  • Posted in Science on 2017-04-28 18:56:10
    Martian Soil Could Be Used to Build a Colony..read more
    Posted in Business on 2017-04-28 18:45:58
    President Trump’s Tax Plan Would Give Alphabet $47B..read more
    Posted in Medicine on 2017-04-28 18:33:57
    Test may spot glaucoma before symptoms begin..read more
    Posted in Science on 2017-04-27 18:20:45
    The Next Journey To Pluto Is Now On Plot..read more
    Posted in Science on 2017-04-27 18:12:13
    Air pollution: 'Heart disease link found'..read more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in about.....read more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for commercial.....read more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 Downloads..read more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into new.....read more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs,.....read more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for commercial.....read more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short Sighted..read more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, but.....read more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in about.....read more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target mitochondria..read more

Recent Blog Posts

  • Posted by AlexMuller
    Nanoparticle vaccine shows potential as immunotherapy to fight.....read more
    Posted by AlexMuller
    Obesity is top cause of preventable life-years lost, study shows..read more
    Posted by AlexMuller
    Light can be utilized to control gene function..read more
    Posted by AlexMuller
    Brain stimulation restores memory during lapses, research shows..read more
    Posted by AlexMuller
    Wax worm caterpillar will eat plastic shopping bags: New.....read more

Login to your Account

Login to your PlanetTech Account here

Username:
Password:
Remember me
or

Create a New Account

You just need username and password

The following errors occured:
Username:
Email:
Password:
Verify password:
Remember me