Social Media Sidebar

Announcement

Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

We are all now connected by the Internet, like neurons in a giant brain.

 

Stephen Hawking

 

3D 'mini-retinas' grown from mouse and human stem cells

RATE THIS! +25
Posted in Science on 4th Apr, 2016 12:39 PM by AlexMuller

Stem cell science has progressed so that researchers can now share recipes for making human retinas, the part of the eye that is sensitive to light. The first protocols enabled the generation of retinal cells in laboratory plates and more recently as complex tissue in the form of tiny eye-like cups.

 

Researchers in Germany now have another efficient way to make 3-D retina organoids, which mimic the organ's tissue organization, from mouse or human stem cells. Their version of "mini-retinas," offers new perspectives on retina growth, injury, and repair.

 
Stem cell technologies have the potential to develop therapies for the treatment of diseases such as age-related blindness, and as clinical researchers work to apply the cells into new therapies, stem cell biologists such as Karl have been working to understand the regeneration of neurons from lower vertebrates to humans, which can aid regenerative medicine.
 
"Even with our new additions to existing organoid systems, we have not yet reached that tipping point of robustness that we need for people without the expertise to grow these models," says Karl, "By working out the details, we also hope to help those who are not developmentally or stem cell-minded to just go and study what they want."
 
The Karl Lab's change to the mini-retina protocol involves cutting a retina organoid grown from stem cells into three pieces at an early stage of eye development. Each of these pieces, which look like little half moons, eventually grows into the full suite of cells found in the retina, thereby increasing the yield of retinal organoids up to 4-fold compared to previous protocols.
 
A trisection also spurs the surviving organoids to grow to reach sizes similar to uncut organoids. These mini-retinas swim around in the dish and because they're not attached to a surface, better reflect the structure of retinal tissue during development.
 
Karl's next objective is to make his 3-D "mini-retinas" even more complex, perhaps by bringing in blood vessels, as well as to use the organoids to study regeneration and the function of different neural cell types--specifically, from the human retina.

Tags: eyevisionretinacellsstem cellsregenerative medicine

Read original article » Back to category

Comments



 

Recent headlines

  • Posted in Medicine on 2017-08-15 17:58:46
    'Fat but fit' still risk heart disease..read more
    Posted in Science on 2017-08-15 17:54:29
    Scientists Discover Trove of Volcanoes Hidden Beneath.....read more
    Posted in Business on 2017-08-15 17:48:52
    Why GE's use of Google Glass marks a turning point for AR..read more
    Posted in Business on 2017-08-14 15:12:20
    China installed record 24.4GW of solar in first-half of 2017..read more
    Posted in Science on 2017-08-14 15:07:01
    SpaceX’s next launch will send an HPE supercomputer to.....read more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in about.....read more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for commercial.....read more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 Downloads..read more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into new.....read more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs,.....read more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for commercial.....read more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short Sighted..read more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, but.....read more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in about.....read more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target mitochondria..read more

Recent Blog Posts

  • Posted by AlexMuller
    Newly discovered biomarkers may lead to promising diagnostic.....read more
    Posted by AlexMuller
    Understanding cell segregation mechanisms which help prevent.....read more
    Posted by AlexMuller
    Unique features of individual brains captured..read more
    Posted by AlexMuller
    Lutein, found in leafy greens, may counter cognitive aging..read more
    Posted by AlexMuller
    New surgical strategy offers hope for repairing spinal injuries..read more

Login to your Account

Login to your PlanetTech Account here

Username:
Password:
Remember me
or

Create a New Account

You just need username and password

The following errors occured:
Username:
Email:
Password:
Verify password:
Remember me