Social Media Sidebar

Announcement

Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

'By far the greatest danger of Artificial Intelligence is that people conclude too early that they understand it'

 

Eliezer Yudkowsky

'Garbage disposal' drug may slow Alzheimer’s and other diseases

RATE THIS! +35
Posted in Science on 25th Dec, 2015 12:31 AM by AlexMuller

Rolipram, a drug that boosts activity in the brain’s “garbage disposal” system, can decrease levels of toxic proteins associated with Alzheimer’s disease and other neurodegenerative disorders and improve cognition in mice, a new study by neuroscientists has found.

 
Rolipram causes nausea, but similar drugs do not, and could be tested in clinical trials quickly, the researchers say.
 
“This has the potential to open up new avenues of treatment for Alzheimer’s and many other neurodegenerative diseases,” said study leader Karen E. Duff, PhD, professor of pathology and cell biology at Columbia University Medical Center (CUMC) and New York State Psychiatric Institute (NYSPI).
 
To remain healthy, brain cells must continually clear out old, worn, or damaged proteins. This task is performed by a small molecular called the proteasome, which works like a kitchen garbage-disposal system, grinding up the old proteins so they can be recycled into new ones.
 
However, in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s, proteins tagged for destruction accumulate in the brain’s neurons. This suggests that the cell’s proteasomes are impaired.
 
The cause for this: tau; a protein that accumulates in Alzheimer’s and other brain diseases, sticks to the proteasome and jams up the protein garbage-disposal process, the researchers first discovered (using a genetically engineered mouse).
 
In the new research, administering rolipram activated the proteasome and restored protein disposal. The drug also improved memory in diseased mice to levels seen in healthy mice.
 
Rolipram has been tested before in mice, and was shown to improve memory. But the new research shows a previously unknown function of the drug: it produces a physical change in the proteasome and increases its activity.
 
Duff says we still don’t know exactly which form of a particular protein is toxic to the brain, which has made it difficult to develop drugs to treat neurodegenerative diseases. “In Alzheimer’s disease, the problem is compounded because several types of abnormal protein can accumulate in a person’s brain, including amyloid, tau, alpha-synuclein, and TDP43.
 
However, the researchers think that “a well-functioning proteasome will be able to clear out everything at once,” she says, including Alzheimer’s, frontotemporal degeneration, Huntington’s, and Parkinson’s.

Tags: brainAlzheimer'sdrugdementiaresearchhealthmedicine

Read original article » Back to category

Comments

Author: Guest
Posted: 2015-12-25
+1
Promising, but very early stages. First our knowledge about “a well-functioning proteasome" has to be more complete before attempts to tackle diseases such as dementia Reply


 

Recent headlines

  • Posted in Business on 2017-03-27 19:48:26
    Tech world debate on robots and jobs heats up..read more
    Posted in Science on 2017-03-27 19:37:58
    Chemical energy storage with water heating solar panels.....read more
    Posted in Science on 2017-03-27 19:31:49
    Blood test detects cancer and pinpoints location before.....read more
    Posted in Business on 2017-03-26 19:56:28
    The U.S. will be hit worse by job automation than other.....read more
    Posted in Business on 2017-03-26 19:49:51
    Elon Musk says Tesla will start taking orders for Solar.....read more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in about.....read more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for commercial.....read more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 Downloads..read more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into new.....read more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs,.....read more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for commercial.....read more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short Sighted..read more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, but.....read more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in about.....read more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target mitochondria..read more

Recent Blog Posts

  • Posted by AlexMuller
    Intensive medical treatment can reverse type 2 diabetes..read more
    Posted by AlexMuller
    Daily consumption of tea protects the elderly from cognitive.....read more
    Posted by AlexMuller
    New analysis method of metabolites accurately predicts whether.....read more
    Posted by AlexMuller
    Unproven stem cell 'therapy' blinds three patients at Florida.....read more
    Posted by AlexMuller
    Indigenous South American group has healthiest arteries of all.....read more

Login to your Account

Login to your PlanetTech Account here

Username:
Password:
Remember me
or

Create a New Account

You just need username and password

The following errors occured:
Username:
Email:
Password:
Verify password:
Remember me