Social Media Sidebar


Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

When seen through the lens of technology, few resources are truly scarce; they’re mainly inaccessible. 


Peter Diamandis

A new class of anti-obesity compounds with potential anti-diabetic properties

Posted in Science on 25th Sep, 2015 06:30 PM by AlexMuller

A molecule known as MnTBAP has rapidly reversed obesity in mice and could be effective for humans in the future, according to researchers from the University of Pennsylvania. “In the span of a month, mice with pre-existing obesity lost 20 percent of their body weight and about 50 percent of their fat mass.”


The weight loss is explained partly by a decrease in food consumption, but other mechanisms are also at play, according to the study published Wednesday (Sept. 23, 2015) in an open-access paper in PLOS One.

The authors report that MnTBAP also has beneficial effects on type 2 diabetes by improving insulin action in muscle and fat. Insulin is the hormone that allows tissues to take up glucose. “In type 2 diabetics, insulin action is impaired, causing the pancreas to go into overdrive in an attempt to maintain normal blood glucose levels.
“Over time, the pancreas becomes exhausted and can’t keep up, leading to rising blood glucose levels and the development of diabetes,” Jonathan Brestoff, the study’s first author, said in an exclusive interview with KurzweilAI. Brestoff is now at the Perelman School of Medicine at the University of Pennsylvania.
He said this molecule represents “a new class of anti-obesity compounds with potential anti-diabetic properties.” He has co-founded the biotech company Symmetry Therapeutics, Inc. to translate the team’s science into clinical applications to treat obesity via an anti-obesity compound called SYM401.
Symmetry is taking an unusual approach with its drug development by crowdfunding part of its research on the platform IndieGoGo. Brestoff said their efforts have gained international attention for attempting to add transparency to an otherwise secretive industry, and have attracted donations and private investors. Their campaign ends October 6, 2015.
On Monday Sept. 21, the CDC published new statistics on obesity in the United States indicating that it remains one of the biggest public health problems facing this country.

Tags: healthmedicinedrugobesityresearchdiabetesfoodnutrition

Read original article » Back to category


Author: Guest
Posted: 2015-09-26
Interesting observations, however, we need to know much more about MnTBAP and more about its effects that can be observed and studied in mice before the relevance for human obesity can be tested
1 Replies
Author: Guest
Posted: 2015-09-26
I agree and have to say that differences between animal models and patients could be huge Reply


Recent headlines

  • Posted in Science on 2018-02-22 14:29:29
    Anti-depressants: Major study finds they more
    Posted in Business on 2018-02-22 14:26:39
    Can Waymo dominate self driving? more
    Posted in Software on 2018-02-22 14:18:49
    Virtual reality is poised for big business-to-business more
    Posted in Science on 2018-02-21 19:34:13
    More sea-level rise for each delay in peaking more
    Posted in Medicine on 2018-02-21 19:31:27
    Cancer Vaccines May Overhaul Cancer Therapy in the more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs, more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target more

Recent Blog Posts

  • Posted by AlexMuller
    Martian landscapes formed from sand 'levitating' on a more
    Posted by AlexMuller
    Scientists detect comets outside our solar more
    Posted by AlexMuller
    Advanced artificial limbs mapped in the more
    Posted by AlexMuller
    Bacteria have a sense of more
    Posted by AlexMuller
    Recurrent brain cancer: New hope with phase 1 clinical more

Login to your Account

Login to your PlanetTech Account here

Remember me

Create a New Account

You just need username and password

The following errors occured:
Verify password:
Remember me