Social Media Sidebar

Announcement

Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

When seen through the lens of technology, few resources are truly scarce; they’re mainly inaccessible. 

 

Peter Diamandis

A nose like sensor array that smells different cancers

RATE THIS! +4
Posted in Science on 17th Sep, 2012 08:38 PM by AlexMuller

The sensor array system contains gold nanoparticles and proteins that “smell” different cancer types in much the same way our noses identify and remember different odors. It builds on Rotello and colleagues’ earlier development of a “chemical nose” array of nanoparticles and polymers able to differentiate between normal cells and cancerous ones.

 

Rotello explains: “With this tool, we can now actually detect and identify metastasized tumor cells in living animal tissue rapidly and effectively using the ‘nose’ strategy. We were the first group to use this approach in cells. Now we’ve done it in tissues and organs, which are very much more complex. With this advance, we’re much closer to the promise of a general diagnostic test.”

 

Until now, the standard method for precisely identifying cancer cells used a biological receptor approach: a protein binding to a cancer cell wall. Its major drawback is that one must know the appropriate receptor beforehand. Rotello and colleagues’ tool avoids that by using an array of gold nanoparticle sensors plus green fluorescent protein (GFP) that activates in response to patterns in the proteins found in cancer cells within minutes, assigning a unique signature to each cancer.

 

“Smell ‘A’ generates a pattern in the nose, a unique set of activated receptors, and these are different for every smell we encounter. Smell ‘B’ has a different pattern. Your brain will instantly recognize each, even if the only time you ever smelled it was 40 years ago. In the same way, we can tune or teach our nanoparticle array to recognize many healthy tissues, so it can immediately recognize something that’s even a little bit ‘off,’ that is, very subtly different from normal. The sensitivity is exquisite, and very powerful.”

 

For this work, the researchers took healthy tissue and mouse tumor samples and trained the nanoparticle-GFP sensor array to recognize them and the GFP to fluoresce in the presence of metastatic tissue. Metastases are differentiated from healthy tissue in a matter of minutes, providing a rapid and very general means of detecting and identifying cancer and potentially other diseases using minimally invasive microbiopsies.

 

“It’s sensitive to really subtle differences,” says Rotello. “Even though two cheeses may look the same, our noses can tell a nicely ripe one from a cheese that’s a few days past tasting good. In the same way, once we train the sensor array we can identify whether a tissue sample is healthy or not and what kind of cancer it is with very high accuracy. The sensitivity is impressive from a sample of only about 2,000 cells, a microbiopsy that’s less invasive for patients.”

 

In addition to the high sensitivity, the authors point out, their sensor is able to differentiate between low (parental) and high (bone, adrenal, and ovary) metastases, as well as between site-specific cells such as breast, liver, lung and prostate cancers.

 

“Overall, this array-based sensing strategy presents the prospect of unbiased phenotype screening of tissue states arising from genetic variations and differentiation state.” Their next step will be to test the new sensor array method in human tissue samples, the researchers say.

 



Read original article » Back to category

Comments

Author: Guest
Posted: 2012-10-08
+0
I read your post and wsiehd I'd written it Reply


 

Recent headlines

  • Posted in Business on 2017-11-18 21:15:58
    Companies are realising that renewable energy is good for.....read more
    Posted in Hardware on 2017-11-18 21:07:25
    California may reach 50% renewable power goal by 2020; 10.....read more
    Posted in Hardware on 2017-11-17 18:02:34
    Tesla unveils a truck and a roadster..read more
    Posted in Hardware on 2017-11-17 17:47:38
    SpaceX expects government support for development of BFR.....read more
    Posted in Science on 2017-11-17 13:59:11
    Gene therapy infused into persons blood to correct liver.....read more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in about.....read more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for commercial.....read more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 Downloads..read more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into new.....read more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs,.....read more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for commercial.....read more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short Sighted..read more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, but.....read more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in about.....read more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target mitochondria..read more

Recent Blog Posts

  • Posted by AlexMuller
    Martian landscapes formed from sand 'levitating' on a little.....read more
    Posted by AlexMuller
    Scientists detect comets outside our solar system..read more
    Posted by AlexMuller
    Advanced artificial limbs mapped in the brain..read more
    Posted by AlexMuller
    Bacteria have a sense of touch..read more
    Posted by AlexMuller
    Recurrent brain cancer: New hope with phase 1 clinical trial.....read more

Login to your Account

Login to your PlanetTech Account here

Username:
Password:
Remember me
or

Create a New Account

You just need username and password

The following errors occured:
Username:
Email:
Password:
Verify password:
Remember me