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A shot against heart attacks?

RATE THIS! +35
Posted in Science on 13th Jun, 2014 01:16 AM by AlexMuller

Harvard Stem Cell Institute (HSCI) scientists collaborating with researchers at the University of Pennsylvania have developed a “genome-editing” approach for permanently reducing cholesterol levels in mice through a single injection, a development that could reduce the risk of heart attacks in humans by 40 to 90 percent.

 
“For the first iteration of an experiment, this was pretty remarkable,” said Kiran Musunuru of HSCI, an assistant professor in Harvard’s Department of Stem Cell and Regenerative Biology (SCRB), and a cardiologist at Harvard-affiliated Brigham and Women’s Hospital. Musunuru stressed, however, that it could take a decade of concerted effort to get this new approach for fighting heart disease from the laboratory to phase I clinical trials in humans.
 
The research was published online today by Circulation Research, a journal of the American Heart Association. Qiurong Ding, a postdoctoral fellow in Musunuru’s laboratory, is first author on the paper. The work by the Musunuru team and a Penn team led by Daniel J. Rader, an authority on cholesterol metabolism and a long-time collaborator of Musunuru, focused on altering the function of a liver gene called PCSK9.
 
In 2003, a group of researchers in France studying families with very high cholesterol levels and very early heart attacks discovered that PCSK9 was a cholesterol regulator, because they found that mutations in this gene seemed to be responsible for the high cholesterol levels and the heart attacks. These mutations are extremely rare and are limited to a few families.

Tags: heartheart diseasegeneticsDNAVaccine

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Comments

Author: Guest
Posted: 2014-06-13
+4
I think that the main point here is personalised treatment of those with the gene for cholesterol regulation affected. Nevertheless, this is very interesting and promising achievement Reply
Author: Guest
Posted: 2014-06-13
+2
With the new genome-editing technology, we can do something we couldn’t do before: make permanent changes in the genome at the level of the DNA. Importantly, we can try to use genome editing to make normal people like people born with the ‘good’ mutations. We know that this works in mice Reply
Author: Guest
Posted: 2014-06-23
+0
The girls recitataion is ecaxtly wht we can say than humans are still trying to find out where the firsts piece of the puzzle go's. There are abt. 200million cars in the US but at five in the morning they are'nt doing anything. They are waiting to play their role, but have'nt started. They may start in the morning. or wait a lifetime and never start. Telepathy. We probably have it. But how to mak it come alive. This girl is wondering where we go after we fall off the edge of the earth. Suprise! Reply


 

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