Social Media Sidebar

Announcement

Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

We are all now connected by the Internet, like neurons in a giant brain.

 

Stephen Hawking

 

Anti-aging gene also enhances cognition

RATE THIS! +6
Posted in Science on 12th May, 2014 11:05 PM by AlexMuller

A variant of the gene KLOTHO is known for its anti-aging effects in people fortunate enough to carry one copy. Now researchers find that it also benefits brain function by increasing overall levels of klotho in the bloodstream and brain. But the improvements in learning and memory associated with klotho elevation aren’t strictly tied to aging.

 

They do occur in aging mice, but also in young animals, according to a report published in the Cell Press journal Cell Reports (open access) on May 8th. That means klotho works to enhance brain power, but in an unexpected way. Aging is a primary risk factor for cognitive decline, lead author Dena Dubal explained. The question was: Would a factor known to play a role in long life have benefits for cognition too?

 
The researchers examined this question in three separate cohorts of people participating in aging studies of various kinds, adding up to more than 700 people. Their analysis showed that people with one of the life-extending variants of the KLOTHO gene scored better on cognitive tests. Because those effects were associated with higher circulating levels of klotho, the researchers turned to genetically engineered mice that express higher-than-normal levels of the life-extending substance.
 
Indeed, klotho worked there too. “Mice with elevated klotho performed twice as well as controls in some cognitive tests, such as remembering where a hidden platform was located in a water maze,” Dubal said. In other tests, the mice did better too, but in some cases only slightly.

Tags: aginggenesgeneticsbraincognition

Read original article » Back to category

Comments

Author: Guest
Posted: 2014-05-13
+1
Encouraging and interesting observation. However, this needs to be put into perspective and recognise that the path from observations on experimental animals to useful drugs that would help humans is usually a long one. After all, mice are not "little men" Reply


 

Recent headlines

  • Posted in Business on 2017-04-29 13:25:52
    Google Is Becoming 'A.I. First'..read more
    Posted in Science on 2017-04-29 13:18:48
    SpaceX looks to break into national security launch.....read more
    Posted in Medicine on 2017-04-29 13:07:03
    China Is Racing Ahead in the Quest to Cure Cancer With.....read more
    Posted in Science on 2017-04-28 18:56:10
    Martian Soil Could Be Used to Build a Colony..read more
    Posted in Business on 2017-04-28 18:45:58
    President Trump’s Tax Plan Would Give Alphabet $47B..read more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in about.....read more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for commercial.....read more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 Downloads..read more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into new.....read more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs,.....read more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for commercial.....read more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short Sighted..read more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, but.....read more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in about.....read more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target mitochondria..read more

Recent Blog Posts

  • Posted by AlexMuller
    Nanoparticle vaccine shows potential as immunotherapy to fight.....read more
    Posted by AlexMuller
    Obesity is top cause of preventable life-years lost, study shows..read more
    Posted by AlexMuller
    Light can be utilized to control gene function..read more
    Posted by AlexMuller
    Brain stimulation restores memory during lapses, research shows..read more
    Posted by AlexMuller
    Wax worm caterpillar will eat plastic shopping bags: New.....read more

Login to your Account

Login to your PlanetTech Account here

Username:
Password:
Remember me
or

Create a New Account

You just need username and password

The following errors occured:
Username:
Email:
Password:
Verify password:
Remember me