Social Media Sidebar

Announcement

Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

People say we're running out of energy. That's only true if we stick with these old 19th century technologies. We are awash in energy from sunlight.

 

Ray Kurzweil

 

Creating living brain cells from deceased Alzheimer’s patients biobanked brain tissue

RATE THIS! +42
Posted in Science on 10th Jan, 2014 12:18 AM by AlexMuller

Scientists at The New York Stem Cell Foundation Research Institute, working in collaboration with scientists from Columbia University Medical Center, have for the first time generated induced pluripotent stem (iPS) cells lines from non-cryoprotected brain tissue of patients with Alzheimer’s.

 
These new stem cell lines will allow researchers to “turn back the clock” and observe how Alzheimer’s develops in the brain, potentially revealing the onset of the disease at a cellular level long before any symptoms associated with Alzheimer’s are displayed. These reconstituted Alzheimer’s cells will also provide a platform for drug testing on cells from patients that were definitively diagnosed with the disease.
 
Until now, the only available method to definitively diagnose Alzheimer’s disease that has been available to researchers is examining the brain of deceased patients. This discovery will permit scientists for the first time to compare “live” brain cells from Alzheimer’s patients to the brain cells of non-Alzheimer’s patients.
 
The scientists successfully produced the iPSCs (induced pluripotent stem cells) from frozen tissue samples stored for up to eleven years at the New York Brain Bank at Columbia University.
 
This advance, published (open access) in Acta Neuropathologica Communications, shows that disease specific iPS cells can be generated from readily available biobanked tissue that has not been cryoprotected, even after they have been frozen for many years. This allows for the generation of iPS cells from brains with confirmed disease pathology and allows access to rare patient variants that have been banked.
 
In addition, findings made using iPS cellular models can be cross-validated in the original brain tissue used to generate the cells. The stem cell lines generated for this study included samples from patients with confirmed Alzheimer’s disease and four other neurodegenerative diseases.

Tags: brainneuroscienceAlzheimer'sdementiahealth

Read original article » Back to category

Comments

Author: Guest
Posted: 2014-01-10
+1
This advance from stem cell research is indeed useful. Having a good model to study cells in culture and also test new potential drugs will be a significant contribution in this field
2 Replies
Author: Guest
Posted: 2014-01-10
+0
The ability to accurately recapitulate the disease in the petri dish is an important advance for this disease. Great
1 Replies
Author: Guest
Posted: 2014-01-10
+0
I think the possibility to turn clock backwards could be particularly informative Reply
Reply
Reply
Author: Guest
Posted: 2014-01-10
+0
Studying neural progenitor cells may also reveal developmental components of familial Alzheimer’s disease, and are more homogenous than the wide variety of neurons currently produced by differentiation protocols Reply
Author: Guest
Posted: 2014-01-10
+1
The genes that can be identified using these cells could provide new targets to help elucidate the cause of the disease as well as provide targets for the discovery of new drugs- very useful applications
4 Replies
Author: Guest
Posted: 2014-01-10
+0
It is important to remember when considering treatments that no one single factor has been identified as a cause for Alzheimer's disease. Reply
Author: Guest
Posted: 2014-01-10
+0
It is likely that a combination of factors, including age, genetic inheritance, environmental factors, lifestyle and overall general health, are responsible. Age appears to be a prominent factor of most of these neurodegenerative disorders Reply
Reply
Author: Guest
Posted: 2014-01-10
+1
Alzheimer's disease and other dementia are serious diseases and the predicted numbers are alarming. Like with cancer, research needs more funding
2 Replies
Author: Guest
Posted: 2014-01-10
+0
Lets hope that G8 can coordinate scientific efforts and recognise what level of funding is needed Reply
Reply
Author: Guest
Posted: 2016-12-26
+0
No senti, ho scoperto il tuo blog solo oggi e sono tipo due ore che leggo post uno dopo l'altro ridendo come una matta. Da sola tra l&9tl;a#3ro.Assolutamente inserita tra i preferiti con la speranza che tu scriva una quantità di post gestibile in futuro. Altrimenti mi licenziano! Reply


 

Recent headlines

  • Posted in Medicine on 2017-08-21 19:26:00
    Darmiyan’s software detects early stages of Alzheimer’s..read more
    Posted in Business on 2017-08-21 19:20:53
    Google needs to pay Apple a fortune to remain the default.....read more
    Posted in Medicine on 2017-08-21 19:15:22
    Artificial Intelligence beats doctors at diagnosing.....read more
    Posted in Science on 2017-08-20 16:55:58
    Computer Approaches Human Skill for First Time in Mapping.....read more
    Posted in Science on 2017-08-20 16:51:23
    Researchers use polystyrene to make next-generation of.....read more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in about.....read more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for commercial.....read more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 Downloads..read more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into new.....read more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs,.....read more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for commercial.....read more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short Sighted..read more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, but.....read more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in about.....read more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target mitochondria..read more

Recent Blog Posts

  • Posted by AlexMuller
    Scientists probe Neptune's depths to reveal secrets of icy.....read more
    Posted by AlexMuller
    New terahertz imaging approach could speed up skin cancer.....read more
    Posted by AlexMuller
    Rebutting the claim that antidepressants do not work..read more
    Posted by AlexMuller
    Artificial neural networks decode brain activity during.....read more
    Posted by AlexMuller
    Four Earth-sized planets detected orbiting the nearest.....read more

Login to your Account

Login to your PlanetTech Account here

Username:
Password:
Remember me
or

Create a New Account

You just need username and password

The following errors occured:
Username:
Email:
Password:
Verify password:
Remember me