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Directing Venom To Fight Cancer

RATE THIS! +40
Posted in Science on 20th Aug, 2014 12:53 AM by AlexMuller

Venom from scorpions or honeybees sounds like it wouldn’t do a person much good. But by directing a modified component just to tumors, researchers might leverage it into a drug. Peptides in some venoms bind to cancer cells and block tumor growth and spread. But they have not yet been developed successfully as anticancer agents because they attack healthy cells too.

 

Bioengineer Dipanjan Pan and coworkers at the University of Illinois, Urbana-Champaign, are now using polymeric nanoparticles to deliver venom toxin directly to cancer cells. Postdoc Santosh K. Misra discussed the work in a session in the Division of Colloid & Surface Chemistry at the American Chemical Society national meeting last week in San Francisco. And Pan, Misra, postdoc Mao Ye, and grad student Sumin Kim reported on it in a paper last month. “To the best of my knowledge, a rational approach to develop a delivery system for venom toxin” has not been tried before, Pan told C&EN.
 
The researchers inserted a derivative of TsAP-1, a toxin peptide from scorpion venom, into spherical polymeric nanoparticles, creating constructs they call NanoVenin. When they used NanoVenin to treat cancerous tissue in the lab, it spared red blood cells (erythrocytes) and other normal cells and killed cancer cells with a potency nearly 10 times that of the toxin alone.

Tags: venombeescancertumorsmedicinedrug

Read original article » Back to category

Comments

Author: Guest
Posted: 2014-08-20
+2
Interesting. Most of the anti- cancer therapies in development relay on small molecules that target cells specifically. Using toxin peptides and nanoparticles to deliver the toxin seems an important route to try Reply
Author: Guest
Posted: 2014-08-20
+1
They found that the venom-laden nanoparticles killed breast cancer cells without detrimental effects to normal cells. We have known for some time that venom toxins have anticancer potential, if only we could deliver them safely and selectively to tumors- that is the next step
2 Replies
Author: Guest
Posted: 2014-08-20
+2
This modified scorpion toxin “is new, and the method of incorporation into nanoparticles is fairly new as well" - good, new option! Reply
Reply
Author: Guest
Posted: 2014-08-20
+2
This is kind of work that will make a difference. Cancer research is achieving improvements. Figures show that half of people in England and Wales now being diagnosed with cancer will survive at least a decade, double the rate in the early 1970s. New treatments have played a role as well as earlier diagnosis and screening.
2 Replies
Author: Guest
Posted: 2014-08-20
+2
Good news! It seems that progress and investment in research is giving good results when it comes to prolonging life. However, the number of cancer cases and also cancer deaths is increasing - more research is needed Reply
Reply
Author: Guest
Posted: 2016-05-06
+0
This shows real exsietrpe. Thanks for the answer. Reply


 

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