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Fungal protein found to cross blood-brain barrier

RATE THIS! +35
Posted in Science on 16th Jun, 2014 12:29 AM by AlexMuller

In a remarkable series of experiments on a fungus that causes cryptococcal meningitis, a deadly infection of the membranes that cover the spinal cord and brain, investigators at UC Davis have isolated a protein that appears to be responsible for the fungus’ ability to cross from the bloodstream into the brain.

 
The discovery, published online June 3 in mBio, the open-access, peer-reviewed journal of the American Society for Microbiology, has important implications for developing a more effective treatment for Cryptococcus neoformans, the cause of the condition, and other brain infections, as well as for brain cancers that are difficult to treat with conventional medications. 
 
“This study fills a significant gap in our understanding of how C. neoformans crosses the blood-brain barrier and causes meningitis,” said Angie Gelli, associate professor of pharmacology at UC Davis and principal investigator of the study. “It is our hope that our findings will lead to improved treatment for this fungal disease as well as other diseases of the central nervous system.”
 
Normally the brain is protected from bacterial, viral and fungal pathogens in the bloodstream by a tightly packed layer of endothelial cells lining capillaries within the central nervous system, the so-called blood-brain barrier. Relatively few organisms, and drugs that could fight brain infections or cancers, can breach this protective barrier.

Tags: braininfectionmeningitiscancerhealth

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Comments

Author: Guest
Posted: 2014-06-16
+3
Now when one protein that can cross the blood/brain barrier has been identified, it should be possible to similar ones or make them synthetically and attempt to use them in treatments. This would require more research bur looks promising Reply
Author: Guest
Posted: 2014-06-23
+0
Journalists love whlitse-blowers. Just not when the whlitse is blown on them. Journalists love transparency. As long as they’re not the ones being exposed. No steadfast journalism rule is unbendable when it comes to justifying and protecting the racket that is modern journalism, specifically, political journalism in the United States today. The ends justify the means . They lie when they claim to be objective. They lie when they claim to be unbiased, because these so called truth seekers are guilty of engaging in open political warfare. And when the whlitse is blown, they simply double down. The news papers are firing, can they just fire the spin doctors?I don't want journalist that lie. I want ones that print the truth. Reply


 

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