Social Media Sidebar

Announcement

Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

We are all now connected by the Internet, like neurons in a giant brain.

 

Stephen Hawking

 

Gene Therapy May Be Our Newest, and Most Effective, Weapon Against Alzheimer’s Disease

RATE THIS! +56
Posted in Science on 8th Sep, 2015 12:21 AM by AlexMuller

In 2001, a team of neurologists in San Diego began testing an experimental treatment for Alzheimer’s: Using tiny pieces of skin taken from the backs of eight patients with Alzheimer’s disease, the team isolated a long-living type of connective tissue cells.

 

Then, using a virus as a delivery system, they genetically modified the cells to synthesize and secrete a potential therapeutic protein known as NGF, effectively turning the cells into little biological drug minipumps. Finally, the team implanted these mutant skin cells directly into each patient’s basal forebrain. Cells in this area are among the first to die from the disorder, and the scientists wanted to see whether NGF could help rescue the atrophy. Then they waited. For 10 years.

 

If this sounds crazy to you, you’re not alone. Fiddling with the human genome in a safe and effective way is notoriously difficult, especially when it comes to the brain. Yet against all odds, the gene therapy seemed to work. Published in the current issue of JAMA Neurology, the autopsy results show that the transplanted cells reliably pumped out NGF in the patients’ brains, which in turn enhanced the cells’ size and their ability to sprout new neural fibers.
 
What’s more, the treatment rescued vulnerable cells from dying, even if they already showed the trademark signs of Alzheimer’s pathology. In some patients, these beneficial effects lasted almost the entire 10 years after they first received the treatment.
 
The trial “very unequivocally (showed) that degenerating neurons can respond to NGF” lead author Dr. Mark Tuszynski told Singularity Hub.

Tags: Alzheimer'sdementiaresearchgene therapybraindiseasecells

Read original article » Back to category

Comments

Author: Guest
Posted: 2015-09-08
+1
It is amazing that this gene therapy progressed through clinical trials and now needs move work in the clinic before it can be used as a treatment - god news! Reply


 

Recent headlines

  • Posted in Business on 2017-05-27 11:41:40
    Google reportedly launched an AI investment program..read more
    Posted in Software on 2017-05-27 11:31:03
    How chatbot artificial intelligence will evolve over the.....read more
    Posted in Medicine on 2017-05-27 11:24:28
    Mind-Controlled Computer Retrains Stroke Victims' Brains.....read more
    Posted in Business on 2017-05-26 15:00:47
    Solar jobs growing 17 times faster than US economy..read more
    Posted in Science on 2017-05-26 14:50:23
    Schiaparelli: Crashed lander was ill-prepared for Mars..read more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in about.....read more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for commercial.....read more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 Downloads..read more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into new.....read more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs,.....read more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for commercial.....read more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short Sighted..read more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, but.....read more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in about.....read more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target mitochondria..read more

Recent Blog Posts

  • Posted by AlexMuller
    Nanoparticle vaccine shows potential as immunotherapy to fight.....read more
    Posted by AlexMuller
    Obesity is top cause of preventable life-years lost, study shows..read more
    Posted by AlexMuller
    Light can be utilized to control gene function..read more
    Posted by AlexMuller
    Brain stimulation restores memory during lapses, research shows..read more
    Posted by AlexMuller
    Wax worm caterpillar will eat plastic shopping bags: New.....read more

Login to your Account

Login to your PlanetTech Account here

Username:
Password:
Remember me
or

Create a New Account

You just need username and password

The following errors occured:
Username:
Email:
Password:
Verify password:
Remember me