Social Media Sidebar


Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

Just because something doesn’t do what you planned it to do doesn’t mean it’s useless.


Thomas Edison

Genetically Altered Bacteria Prevent Mice From Getting Fat

Posted in Science on 28th Jun, 2014 03:29 AM by AlexMuller

By feeding mice a genetically modified version of E. coli, a bacterium that naturally lives in guts, scientists were able to prevent them from gaining as much weight as mice not given the treatment. The microbes were made to express a substance called NAPE, which mice and humans convert into a hormone when food is digested.


This hormone then moves through the bloodstream to the brain, and reduces appetite. The idea is that mice with this new bug in their guts thought they were eating more than they were, without any apparent ill effects. In the study, published in The Journal of Clinical Investigation, mice given the microbe and un-dosed animals were both put on a high-fat diet.


The animals given the bacteria (in their drinking water) ate less and gained less weight, and also showed less insulin resistance, a marker for diabetes. The finding raises the possibility that these bacteria, which basically amount to an engineered probiotic, could be imported into humans to do the same thing. That's obviously a ways off and hypothetical at this point, since mice are not humans.

Tags: miceobesityfatdietnutritionbacteriagenetics

Read original article » Back to category


Author: Guest
Posted: 2014-06-28
Yes, I agree with this last statement. Mice are not "little people" and many ideas and test in drug development fail precisely at this point- in clinical trials. Let us hope that in this case, modified bacteria will do the same job in human gut Reply
Author: Guest
Posted: 2014-06-28
Given the failure of many recent anti-obesity drugs, if the microbe could be safely used in humans, it would be great step forward in treatments for obesity. The bacteria appear to last in the gut for about four weeks, a long period of time between interventions that would trump taking a pill everyday Reply


Recent headlines

  • Posted in Science on 2019-01-05 00:26:50
    China Lands Chang'e 4 on the Far Side of the more
    Posted in Science on 2018-12-31 00:24:45
    Support for Human Gene Editing to Fix Diseases in more
    Posted in Science on 2018-12-31 00:15:06
    Will Mimicking The Nervous System Advance more
    Posted in Science on 2018-12-26 15:04:48
    NASA Gives Us Sugar in Space to Confirm Building more
    Posted in Business on 2018-12-21 22:48:10
    US Air Force Funds SpaceX Starlink For $28.7 more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs, more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target more

Recent Blog Posts

  • Posted by AlexMuller
    Even light drinking increases risk of more
    Posted by AlexMuller
    Researchers have discovered how to slow more
    Posted by AlexMuller
    Human retinas grown in a dish explain how color vision more
    Posted by AlexMuller
    The smartphone app that can tell you’re depressed before more
    Posted by AlexMuller
    Neural networks don’t understand what optical illusions more

Login to your Account

Login to your PlanetTech Account here

Remember me

Create a New Account

You just need username and password

The following errors occured:
Verify password:
Remember me