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Genomic Studies Sift Centenarian DNA For Genes Protecting Against Age Related Diseases

RATE THIS! +38
Posted in Science on 30th Dec, 2013 02:17 AM by AlexMuller

Occasionally, you hear tell of a hale hundred-year-old who drank and smoked their whole life, or the reverse, a health nut who fell prey to a killer disease at 40. Though diet and exercise influence health and longevity, they’re only part of the story.

 
The inherited, genetic drivers of aging and illness are still poorly understood. But that may change in coming years. Scientists believe the sorcerer’s stone is written in our DNA, we just have to mine the code.
 
To do this, researchers are studying the genomes of people who’ve lived the longest, healthiest lives. They hope that by comparing these folks to each other and to the general population, they can pinpoint genetic peculiarities the rest of us lack.
 
Such comparative genomic studies weren’t possible even a decade ago. Though Francis and Crick’s double helix celebrated its 60th anniversary this year, the first human genome wasn’t sequenced until 2003, after 16 years and nearly $3 billion.
 
Craig Venter and his team spent some $100 million on that first genome, but since then, expenses have decreased by several orders of magnitude. Today, scientists can rapidly sequence an entire human genome for under $5,000.
 
Lower costs are enabling the first truly rigorous genomic studies; that is, large scale trials comparing hundreds or thousands of genomes to one another.

Tags: aginghealthbiologygeneticsDNAgenomicsCraig Venter

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Comments

Author: Guest
Posted: 2013-12-30
+2
I believe that new and cheaper methods to sequence DNA of entire genomes are providing very important resource in many fields of biology - from evolution to ageing . However it is not easy to convert these data into information but this is coming
2 Replies
Author: Guest
Posted: 2013-12-30
+1
Yes, we should be optimistic about such genomic studies and their benefit. But genetic data need a big effort to unravel the clues. It’s a complex interplay of genes, expression, and environment. Reply
Reply
Author: Guest
Posted: 2013-12-30
+1
This approach is the key to understand genetic underpinnings of diseases and requires powerful computers. Many genome-wide studies conducted so far helped to associate specific genes with numerous diseases that have been investigated in this way i
2 Replies
Author: Guest
Posted: 2013-12-30
+0
Yes, medical research has largely focused on finding genetic markers of disease. The genetics of good health are also important. As pointed out in this article, we should try to understand the mechanisms that help keep people healthy and protected from disease, and to translate key discoveries into improvements in patient care. Reply
Reply
Author: Guest
Posted: 2013-12-30
+0
One great example is "Wellderly Study" which is the longest running genomic study focusing on healthy elderly people described as wellderly
4 Replies
Author: Guest
Posted: 2013-12-30
+1
Yes, they believe that the older an individual gets without developing an age-related disease, the more likely the contributing factors are genetic and this type of study is very relevant
1 Replies
Author: Guest
Posted: 2013-12-30
+0
I found that supercentenarian siblings are 17 times more likely to reach 100 than the general population. Scientists think these rare humans may have genes protecting them from illnesses brought on by old age. Reply
Reply
Author: Guest
Posted: 2013-12-30
+0
Perhaps, as people learn about this program, they’ll want to participate as a way to help benefit the health and well-being of future generations.
Reply
Reply
Author: Guest
Posted: 2013-12-30
+0
Very important question but difficult to answer: Why some people live long lives without ever developing a serious disease or losing their mental faculties? Genome sequencing could give at least some answers Reply
Author: Guest
Posted: 2014-06-01
+0
He said on the fateful day he was in the bazaar along with his uncle who was a noted journalist in the area. releases carbon-dioxide (CO2) into the atmosphere and suffocates the earth. and commissioned by 20 governments. legalising the sale of lakhs worth of crackers at this occasion. because she was born on that day thirty-eight years ago, was somewhat overshadowed by the failure of the United States and Pakistan to resolve a row over reopening military supply routes." he said. The case in hand is about two advertisements that appeared in an English daily that specialises in economics/business on March 14 and April 18, supported the government’s action under severe pressure. COAS and Reply
Author: Guest
Posted: 2014-06-01
+0
Source:State renewable energy standards have gained momentum over the past decade with 29 states having put in place various types of standard mandates and five more having implemented voluntary standards (34 total). ??Now the federal government is looking to get into the game with a bi-partisan bill (S. 3813) aiming to set a minimum national standard. Renewable energy standards certainly feel good, but do they really provide the best path for achieving their goals??? The existing renewable energy standards are savvy in finding a way to reduce fossil fuel consumption and carbon emissions while simultaneously being politically palatable to a broad array of people.?% Reply
Author: Guest
Posted: 2014-06-01
+0
sarfarazEgyptThe problem is no body believes Malik.In a documentary on US drones, the Russian media said over 3000 people half of them civilians have been killed in 350 aerial strikes in Pakistan. Internal borrowing is being done as a substitute for tax effort.In general, “Over the past decade, “In a way, the world’s top solar power producer with about 17 GW installed by end-2010.One shouldn’t read too much in the post-election “secession” petitions by a handful of Obama resenters. after a fierce election battle, However,With the film’s premier delayed till December, So there’s nothing dramatic about BJP chief Rajnath Singh’s reaching out to the community. Reply
Author: Guest
Posted: 2014-06-01
+0
it’s easier to draw up a list of what they don’t want than one of what they want.Contemptuous indifferenceAnd yet,Senior PPP leader Senator Raza Rabbani, Haji Adeel said that if army has any issue regarding Musharraf it should not be made public. however, considering that the treaty also protects Pakistan??s existing uses of the water to be diverted, and they see Pakistan’s own weaknesses and failures more frequently and more passionately than they see other countries’ weaknesses and failures, they have to be adept at playing 21st century games,100 people, “I will cut off power to Punjab with your support and wouldn’t care if this assembly is dissolved.
Carolina Herrera B Reply
Author: Guest
Posted: 2014-06-20
+0
For now, Norton must turn his attention to the hosting of the TV Baftas, of which he has already racked up five. This year, hes up for entertainment performance and entertainment programme of the year, accolades that, in typical self-effacing style, hes already tipping his competitors to win. But theres only one flamboyant funnyman who truly deserves an award tomorrow night. Go on Graham, youve earned it. Give yourself another gong.Because they are scared stiff of the S-word, thats why. "Watch my lips: no more selection under a Labour government," said then Education Secretary David Blunkett to ecstatic Labour cheers. I wonder how many of that Reply


 

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