Social Media Sidebar

Announcement

Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

'By far the greatest danger of Artificial Intelligence is that people conclude too early that they understand it'

 

Eliezer Yudkowsky

The human brain may age less than was previously thought

RATE THIS! +45
Posted in Science on 5th Mar, 2015 09:42 PM by AlexMuller

A fundamental problem of fMRI is that it measures neural activity indirectly through changes in regional blood flow. Thus, without careful correction for age differences in vasculature reactivity, differences in fMRI signals can be erroneously regarded as neuronal differences.

 

An important line of research focuses on controlling for noise in fMRI signals using additional baseline measures of vascular function. However, such methods have not been widely used, possibly because they are impractical to implement in studies of ageing.

 
An alternative candidate for correction makes use of resting state fMRI measurements, which is easy to acquire in most fMRI experiments. While this method has been difficult to validate in the past, the unique combination of an impressive data set across 335 healthy volunteers over the lifespan, as part of the CamCAN project ( www.cam-can.org), allowed Dr. Kamen Tsvetanov and colleagues to probe the true nature of ageing effects on resting state fMRI signal amplitude.
 
Their research showed that age differences in signal amplitude during a task are of a vascular, not neuronal, origin. They propose that their method can be used as a robust correction factor to control for vascular differences in fMRI studies of ageing.
 
The study also challenged previous demonstrations of reduced brain activity in visual and auditory areas during simple sensorimotor tasks. Using conventional methods, the current study replicated these findings. However, after correction, Tsvetanov et al.
 
Results show that it might be vascular health, not brain function, that accounts for most age-related differences in fMRI signal in sensory areas. Their results suggest that the age differences in brain activity may be overestimated in previous fMRI studies of ageing.

Tags: brainbloodfMRIneuroscienceaginghealthmedicine

Read original article » Back to category

Comments

Author: Guest
Posted: 2015-03-06
+1
To make a definitive conclusion there is a need for a range of experimental methods to be applied and not just relay on fMRI Reply


 

Recent headlines

  • Posted in Science on 2017-04-23 16:03:05
    Google's universal quantum computer could become world's.....read more
    Posted in Medicine on 2017-04-23 15:51:27
    Anti-dementia drugs will soon start clinical trials..read more
    Posted in Business on 2017-04-23 15:47:18
    Robots can handle a third of our workplace tasks, study.....read more
    Posted in Science on 2017-04-22 15:31:01
    Proposed Mission to find life on Saturn’s moon Enceladus..read more
    Posted in Medicine on 2017-04-22 14:32:54
    Global plan to wipe out hepatitis..read more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in about.....read more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for commercial.....read more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 Downloads..read more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into new.....read more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs,.....read more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for commercial.....read more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short Sighted..read more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, but.....read more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in about.....read more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target mitochondria..read more

Recent Blog Posts

  • Posted by AlexMuller
    Intensive medical treatment can reverse type 2 diabetes..read more
    Posted by AlexMuller
    Daily consumption of tea protects the elderly from cognitive.....read more
    Posted by AlexMuller
    New analysis method of metabolites accurately predicts whether.....read more
    Posted by AlexMuller
    Unproven stem cell 'therapy' blinds three patients at Florida.....read more
    Posted by AlexMuller
    Indigenous South American group has healthiest arteries of all.....read more

Login to your Account

Login to your PlanetTech Account here

Username:
Password:
Remember me
or

Create a New Account

You just need username and password

The following errors occured:
Username:
Email:
Password:
Verify password:
Remember me