Social Media Sidebar


Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

Just because something doesn’t do what you planned it to do doesn’t mean it’s useless.


Thomas Edison

Major steps toward a bioengineered heart for transplantation

Posted in Science on 21st Mar, 2016 10:30 AM by AlexMuller
Using a patient’s own cells would help to overcome some of the problems associated with receiving a donated heart, including immune rejection, as well as the long-term side effects of life-long treatment with the immunosuppressive drugs. To achieve this, the research team had to overcome three major technical challenges:
1. Create a structural scaffold from a human heart
One challenge is producing a structural scaffold able to support new functioning heart cells. To do this, the researchers take a human heart and remove the heart muscle and other cells and components that would stimulate the recipient’s immune system to reject the organ. Once stripped, the structural and connective tissues that give the heart its 3D structure are left behind.
If researchers can re-seed this structural scaffold with viable heart-like cells from the patient who will receive the heart (steps 2 and 3 below), the engineered heart would have the potential to reduce the risk of rejection and the resulting need for long-term immunosuppressive treatment.
Team leader Harald Ott, MD, an assistant professor of surgery at Harvard Medical School, has pioneered a method for stripping the living cells from donor organs and then re-populating the remaining scaffold with new cells.*
2. Grow cells that will function and contract like heart cells
Another challenge is developing a method that will enable researchers to use cells from the potential heart recipient to produce cells that will function like heart cells. These are generated from induced pluripotent stem cells (iPSCs), cells with the potential to be turned into many different types of cells.
The team generated the heart-like muscle cells from reprogrammed skin cells. Once they had checked the quality of these cells, they grew them in the laboratory for several days and showed that the cells developed into tissue that spontaneously contracted like heart cells.**
3. Re-seed the human heart scaffold and grow it in an automated bioreactor
The final challenge was developing an automated bioreactor system capable of supporting a whole human heart while the re-seeded heart cells take hold. In this initial study, the researchers only partially re-seeded the scaffold, many more cells would be needed to totally re-populate a functioning heart scaffold.
After incubating the engineered heart in the bioreactor, the researchers showed that the regenerated tissue behaved like immature cardiac muscle tissue that was able to contract in response to electrical stimulation.
Next steps
“Regenerating a whole heart is most certainly a long-term goal that is several years away,” says Guyette. “Among the next steps that we are pursuing are improving methods to generate even more cardiac cells.”
He says re-seeding a whole heart would take tens of billions of cells, so the team needs to optimize the bioreactor techniques to improve the maturation and function of engineered cardiac tissue.
They also need to integrate the electrical function of the regenerated tissue in the bioengineered heart. In the meantime, Guyette says the team is working on engineering a functional myocardial patch that could be used to replace tissue damaged after a heart attack or heart failure.

Tags: heartbiotechnologystem cellshealthmedicineresearchheart transplant

Read original article » Back to category


Author: Guest
Posted: 2016-03-22
Fantastic progress! Regenerating entire organ is a difficult task and it is nearly achieved in the case of human hearth, some more years to wait however.... Reply


Recent headlines

  • Posted in Science on 2018-06-17 23:45:17
    SpinLaunch raises $40M from Airbus, Google and others more
    Posted in Science on 2018-06-17 01:08:50
    New eyedrops could repair corneas, make glasses more
    Posted in Science on 2018-06-17 01:02:51
    121 giant exoplanets in habitable zones may more
    Posted in Science on 2018-06-16 00:25:58
    Mars Opportunity: Rover 'should ride out storm' more
    Posted in Software on 2018-06-16 00:15:52
    DeepMind AI can 'imagine' a world based on a more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs, more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target more

Recent Blog Posts

  • Posted by AlexMuller
    In five years quantum computing will be more
    Posted by AlexMuller
    Google partners with Johnson and Johnson to make lower more
    Posted by AlexMuller
    Electron holography microscope with spatial resolution down more
    Posted by AlexMuller
    Lower cost advanced Nuclear power could dominate future US more
    Posted by AlexMuller
    Why Hasn’t AI Mastered Language Translation? more

Login to your Account

Login to your PlanetTech Account here

Remember me

Create a New Account

You just need username and password

The following errors occured:
Verify password:
Remember me