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'By far the greatest danger of Artificial Intelligence is that people conclude too early that they understand it'

 

Eliezer Yudkowsky

Nanoparticle Completely Eradicates Hepatitis C Virus

RATE THIS! +3
Posted in Science on 19th Jul, 2012 09:33 AM by AlexMuller

The nanoparticle, dubbed a nanozyme, consists of a backbone made from gold nanoparticles and a surface with two biological components. One biological component is an enzyme that attacks and destroys the mRNA, which provides the recipe for duplicating the protein that causes the disease. The other biological part is the navigator, if you will. It is a DNA oligonucleotide that identifies the disease-related protein and sends the enzyme on course to destroy it.

 

Y. Charles Cao, a UF associate professor of chemistry, and Dr. Chen Liu, a professor of pathology at the UF College of Medicine published their research online this week in the Proceedings of the National Academy of Sciences ("Nanoparticle-based artificial RNA silencing machinery for antiviral therapy").

 

The basis of the work is mimicking the biological process of RNA interference, which researchers in the past have used effectively in the laboratory for treating HIV. In the UF research the nanoparticle mimics the function of RNA-induced silencing complex (RISC), which mediates the RNA interference process.

 

Current hepatitis C treatments do attack the replication process of the virus but they are not entirely effective and only help about 50 percent of the patients treated with them. Cao and Liu along with their team wanted to see if they could improve upon that percentage. The researchers claim that their treatment (in cell culture and mice) led to a near 100 percent eradication of the hepatitis C virus without bringing on any side effects caused by the immune system attacking the treatment.

 

Of course, this is a long way from becoming a treatment anytime soon. A major caveat is that the use of nanotreatments for the targeting and destroying of abnormal cells like cancer cells is always problematic since those cells are “still us” as George Whitesides noted some time back.  It’s always a bit of a tricky business to make sure that nanoparticles are targeting those biological processes within us that we want stopped and not the ones we want to keep.

 



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Comments

Author: Guest
Posted: 2012-07-22
+0
Anything that targets viruses has got to be good Reply
Author: Guest
Posted: 2013-09-13
+0
WjH5Ys Great blog.Much thanks again. Great. Reply
Author: Guest
Posted: 2013-09-24
+0
gTYjxG Major thanks for the post.Much thanks again. Great. Reply
Author: Guest
Posted: 2013-10-15
+0
NgvzPP Really enjoyed this blog post.Really looking forward to read more. Really Cool. Reply
Author: Guest
Posted: 2013-10-26
+0
XSdNNB Really enjoyed this blog.Really looking forward to read more. Will read on... Reply
Author: Guest
Posted: 2013-11-01
+0
sNkQDF Thank you ever so for you blog article.Much thanks again. Keep writing. Reply
Author: Guest
Posted: 2014-01-09
+0
PVndrY This is one awesome post.Thanks Again. Will read on... Reply
Author: Guest
Posted: 2014-02-28
+0
ASG8t0 Hey, thanks for the post.Much thanks again. Really Cool. Reply
Author: Guest
Posted: 2014-04-18
+0
vvE5WE Fantastic article.Much thanks again. Much obliged. Reply
Author: Guest
Posted: 2015-06-11
+0
A11sGG Im grateful for the post.Much thanks again. Really Cool. Reply
Author: Guest
Posted: 2015-10-16
+0
RUMwNj Say, you got a nice blog.Really looking forward to read more. Much obliged. Reply


 

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