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Nasal spray could provide highly-targeted treatment for depression

RATE THIS! +45
Posted in Science on 27th Mar, 2014 11:57 PM by AlexMuller

A nasal spray containing a specially-developed protein peptide could form the basis for highly-targeted treatment for depression, new research from the Centre for Addiction and Mental Health has shown. The peptide was found to relieve symptoms of depression, with the lead researcher hopeful of little to no side-effects.

 
The protein peptide was originally developed in 2010 by Dr. Fang Liu, Senior Scientist in the Campbell Family Mental Health Research Institute at CAMH. While the peptide was found to be just as effective as conventional anti-depressants when tested on animals, when administered orally it was unable to cross the blood-brain barrier in sufficient concentrations and therefore had to be injected into the brain.
 
A grant from the Canadian Institute of Health Research then enabled Liu and a team of researchers to explore other methods of delivery. In administering the peptide in the form of a nasal spray, the team found that it was delivered to the right part of the brain to relieve depression-like symptoms in animals.
 
Dr Liu's team had previously found that a binding between two dopamine receptors, the D1 and D2 receptor complex, was higher in the brains of sufferers of major depression. The peptide works by interfering with the binding between these receptors, in effect, working as an anti-depressant.

Tags: brainhealthmental healthdepressionneuroscience

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Comments

Author: Guest
Posted: 2014-03-28
+1
Any progress to help with depression is most welcome. However, this spray seems effective but what advantages it may have compared to other anti- depressants , this not clear
2 Replies
Author: Guest
Posted: 2014-03-28
+3
One thing that is new here is the delivery method. More importantly, the spray is also a new type of treatment for the illness itself, as previous treatments for depression have depended on medications that block serotonin or norepinephrine transporters. Reply
Reply
Author: Guest
Posted: 2014-03-28
+3
Depression is a big problem. In 2012 the World Health Organisation cited depression as the leading cause of disability worldwide- so action is needed as soon as possible!
3 Replies
Author: Guest
Posted: 2014-03-28
+0
It is natural to consider that people evolved to be adapted to particular environment that is consequently lass stressful - cities could be very disturbing with all the crowds and noises Reply
Reply
Author: Guest
Posted: 2014-03-28
+2
Not just medication but also changes in the lifestyle are of great importance. For example, it has been reported recently that Green space can make people happier for years
4 Replies
Author: Guest
Posted: 2014-03-28
+1
Recently it has been suggested that green spaces 'can save NHS billions'. That requires that everyone had access to green spaces. Reply
Author: Guest
Posted: 2014-03-28
+0
I agree that the link between "healthy woods and healthy lives" is a connection that really has to be made much more and much more often. Reply
Reply
Author: Guest
Posted: 2014-03-29
+0
Any progress to help with depression is most welcome. However, this spray seems effective but what advantages it may have compared to other anti- depressants , this not clear Reply
Author: Guest
Posted: 2016-12-26
+0
Pessoal que faz a Capanha de Serra precisa acordar. Pode MELHORAR E MUITO. Quanto ao vicede Serra não importa se for do PSDB ou do DEM - Basta ser simpático e soridrente. Reply


 

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