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New compounds identified that may treat depression rapidly with few side effects

RATE THIS! +47
Posted in Science on 19th Jul, 2015 11:22 PM by AlexMuller

Most people with depression take medications that increase levels of the serotonin in the brain. The most common of these drugs, such as Prozac and Lexapro, are selective serotonin reuptake inhibitors, or SSRIs. SSRIs are effective in only a third of patients with depression.

 

In addition, even when these drugs work, they typically take between three and eight weeks to relieve symptoms. As a result, patients often suffer for months before finding a medicine that makes them feel better. This is not only emotionally excruciating; in the case of patients who are suicidal, it can be deadly. Better treatments for depression are clearly needed.

 
Dr. Thompson and his team focused on another neurotransmitter besides serotonin, an inhibitory compound called GABA. Brain activity is determined by a balance of opposing excitatory and inhibitory communication between brain cells. Dr. Thompson and his team argue that in depression, excitatory messages in some brain regions are not strong enough.
 
Because there is no safe way to directly strengthen excitatory communication, they examined a class of compounds that reduce the inhibitory messages sent via GABA. They predicted that these compounds would restore excitatory strength. These compounds, called GABA-NAMs, minimize unwanted side effects because they are precise: they work only in the parts of the brain that are essential for mood.
 
“These compounds produced the most dramatic effects in animal studies that we could have hoped for,” Dr. Thompson said. “It will now be tremendously exciting to find out whether they produce similar effects in depressed patients. If these compounds can quickly provide relief of the symptoms of human depression, such as suicidal thinking, it could revolutionize the way patients are treated.”

Tags: depressionhealthmindbrainmental healthbiologychemistrydrug

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Comments

Author: Guest
Posted: 2015-07-20
+2
It is about time that new treatments become available for depression that affects so many people - looking forward to find out what happens in clinical trials
1 Replies
Author: Guest
Posted: 2015-07-20
+0
Yes, this is the key. Many observations from cellular studies and animal models never make it to the clinic and this is why more research is needed Reply
Reply
Author: Guest
Posted: 2016-12-26
+0
superb checul!deja mi-e pofta!o combinatie exrtaordinara, sper doar sa nu ingrase.;-))ce-ai zice de un schimb de linkuri.adresa mea e wwl.oodotipoderecetas.bwogspot.ctmsi apropo!poti sa scrii in romaneste pe blogul meu ca sincer nunumai ca te inteleg dar mi-e dor sa mai citesc si un comentariu in romana. Reply


 

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