Social Media Sidebar

Announcement

Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

'By far the greatest danger of Artificial Intelligence is that people conclude too early that they understand it'

 

Eliezer Yudkowsky

New immunotherapy combo effectively treats advanced brain cancer in pre-clinical models

RATE THIS! +54
Posted in Science on 12th Jul, 2016 05:02 PM by AlexMuller

Researchers in the University of California developed a combination treatment, which involves a vaccine activating an immune response against advanced brain cancer. The treatment harnesses an antibody blockade to keep the brain cancer from shielding itself from the immune cells.

 
This way, the patient’s immune cells identify the tumor and attack it. The survival period of people diagnosed with glioblastoma (GBM) is short since it is estimated between 14 to 18 months although the patients undergo various treatments, like chemotherapy, radiation and surgery.
 
According to the article published in the journal JCI Insight, a three year-study shows hopeful results. Drs. Robert Prins, Timothy Cloughesy and Linda Liau as well as all UCLA Jonsson Comprehensive Cancer Center members discovered that when a dendritic cell vaccine is combined with an antibody blockade of an immune cell surface receptor named PD-1 enables an effective immune response against glioblastoma.
 
This results of their findings outline the mechanism by which efficient immune response is seen in brain tumors. “We discovered that effective anti-tumor immunity to glioblastoma must have a significant infiltration of killer T cells and a blockade of the important checkpoint axes that make these killer T cells dysfunctional within the tumor,” said Dr. Prins.
 
The doctor explained that the combination treatment enables the immune system to understand that the GBM is a foreign invader and so it prevents the brain cancer from growing or recurring.
 
The PD1/PD-1 antibody blockade might not be successful in GBM without important T-cell infiltration. The dendritic cell vaccine enables the infiltration of T-cells into the brain tumors whereas the PD-1 antibody blockade removes the shield, which is activated from the tumor in order to hide from the immune system.
 
This is a different approach from prior research in non-small cell lung cancer or metastatic melanoma because it shows that immune response activated by dendritic cell va

Tags: braincanceroncologybrain tumormedicineresearch

Read original article » Back to category

Comments

Author: Guest
Posted: 2016-07-13
+0
Immunotherapy is the latest promise in fight to cure cancer and this effort shows that hopes could be justified - some more work and research need to follow however
1 Replies
Author: Guest
Posted: 2016-07-13
+0
Yes, in particular it would be important to find out which other cancer types and which combinations that include immunotherapy could be treated Reply
Reply


 

Recent headlines

  • Posted in Software on 2017-03-25 14:13:38
    Google Develops A Deep Learning Machine That Could Learn.....read more
    Posted in Medicine on 2017-03-25 14:26:25
    Google’s Calico partners with new biotech firm to.....read more
    Posted in Business on 2017-03-25 14:20:19
    25 US Cities Are Now Committed to 100% Renewable Energy..read more
    Posted in Science on 2017-03-25 14:16:44
    New Lenses Could Give You Super Color Vision..read more
    Posted in Business on 2017-03-24 19:18:37
    This company replaced 90% of its workforce with machines......read more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in about.....read more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for commercial.....read more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 Downloads..read more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into new.....read more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs,.....read more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for commercial.....read more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short Sighted..read more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, but.....read more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in about.....read more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target mitochondria..read more

Recent Blog Posts

  • Posted by AlexMuller
    Intensive medical treatment can reverse type 2 diabetes..read more
    Posted by AlexMuller
    Daily consumption of tea protects the elderly from cognitive.....read more
    Posted by AlexMuller
    New analysis method of metabolites accurately predicts whether.....read more
    Posted by AlexMuller
    Unproven stem cell 'therapy' blinds three patients at Florida.....read more
    Posted by AlexMuller
    Indigenous South American group has healthiest arteries of all.....read more

Login to your Account

Login to your PlanetTech Account here

Username:
Password:
Remember me
or

Create a New Account

You just need username and password

The following errors occured:
Username:
Email:
Password:
Verify password:
Remember me