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'By far the greatest danger of Artificial Intelligence is that people conclude too early that they understand it'

 

Eliezer Yudkowsky

One injection stops diabetes in its tracks:

RATE THIS! +48
Posted in Science on 18th Jul, 2014 12:07 AM by AlexMuller

In mice with diet-induced diabetes, the equivalent of type 2 diabetes in humans, a single injection of the protein FGF1 is enough to restore blood sugar levels to a healthy range for more than two days. The discovery by Salk scientists, published in the journal Nature, could lead to a new generation of safer, more effective diabetes drugs.

 

The team found that sustained treatment with the protein doesn't merely keep blood sugar under control, but also reverses insulin insensitivity, the underlying physiological cause of diabetes. Equally exciting, the newly developed treatment doesn't result in side effects common to most current diabetes treatments.
 
"Controlling glucose is a dominant problem in our society," says Ronald M. Evans, director of Salk's Gene Expression Laboratory and corresponding author of the paper. "And FGF1 offers a new method to control glucose in a powerful and unexpected way."
 
Type 2 diabetes, which can be brought on by excess weight and inactivity, has skyrocketed over the past few decades in the United States and around the world. Almost 30 million Americans are estimated to have the disease, where glucose builds up in the bloodstream because not enough sugar-carting insulin is produced or because cells have become insulin-resistant, ignoring signals to absorb sugar.
 
As a chronic disease, diabetes can cause serious health problems and has no specific cure. Rather it is managed, with varying levels of success, through a combination of diet, exercise and pharmaceuticals. Diabetes drugs currently on the market aim to boost insulin levels and reverse insulin resistance by changing expression levels of genes to lower glucose levels in the blood.
 
But drugs, such as Byetta, which increase the body's production of insulin, can cause glucose levels to dip too low and lead to life-threatening hypoglycemia, as well as other side effects.

Tags: diabetesweightsugarobesityglucoseinsulin

Read original article » Back to category

Comments

Author: Guest
Posted: 2014-07-18
+3
Indeed, this is very unexpected and functions of FGF1 should be researched more extensively. One hopes that the human trials will give us the definitive answer and turn this hope into reality
2 Replies
Author: Guest
Posted: 2014-07-18
+2
Some people see this as "another step towards easy and quick fixes to everyday problems." Well, it just could be but this may not be possible and we better adjust lifestyle, no matter how many difficult efforts this involves Reply
Author: Guest
Posted: 2014-07-18
+1
Our lifestyle is one major cause of health problems and educating people to change and prevent this continue is the priority- Governments should do more Reply
Reply
Author: Guest
Posted: 2014-07-18
+1
Obesity has become a world-wide epidemic. I found that obesity causes an estimated 2.8 million deaths among adults around the world every year. Indeed, an epidemic Reply
Author: Guest
Posted: 2014-07-18
+2
This FGF1 treatment will take time to bring it to human use. There will be clinical trials in step one two three plus further regulatory requirements of whatever kind and all-in-all a 15 year time-span of waiting what can be expected. Fine, as long as it gets to that point! Reply
Author: Guest
Posted: 2014-07-18
+2
Not long ago we had a headline: "Turning off a Fat Accumulation Gene to Reduce Obesity proven in Mice". This FGF1 treatment would be much simpler if proven effective in humans Reply


 

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