Social Media Sidebar

Announcement

Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

Just because something doesn’t do what you planned it to do doesn’t mean it’s useless.

 

Thomas Edison

Optogenetics captures synaptic transmission in live mammalian brain for the first time

RATE THIS! +37
Posted in Science on 27th Dec, 2014 08:51 PM by AlexMuller

EPFL scientists Aurélie Pala and Carl Petersen have observed and measured synaptic transmission in a live animal for the first time, using optogenetics* to stimulate single neurons in the mouse barrel cortex (which processes sensory information from the mouse’s whiskers).

 
They shined blue light on the neurons containing a gene-based light-sensitive protein, activating the neurons to fire. Then using microelectrodes, they measured resulting electrical signals in neighboring interneuron cells. They also used an advanced imaging technique (two-photon microscopy) that allowed them to look deep into the brain of the live mouse and identify the type of each interneuron they were studying.
 
The data showed that the neuronal transmissions from the light-sensitive neurons differed depending on the type of interneuron on the receiving end. Only a few studies have directly investigated synaptic transmission between specific neocortical neurons in vivo, presumably due to the technical difficulties in obtaining intracellular recordings from connected pairs of neurons in vivo, the authors say in their (open-access) paper in Neuron.
 
The research overcomes a limitation of in vitro (lab) studies, where associated biomolecules are different from those in a live animal, and where cutting neural tissue for lab work also introduces artifacts, the researchers suggest. “This is a proof-of-concept study,” says Pala, who received her PhD for this work. “Nonetheless, we think that we can use optogenetics to put together a larger picture of connectivity between other types of neurons in other areas of the brain.”

Tags: brainneuronsneurosciencecellssciencemedicine

Read original article » Back to category

Comments

Author: Guest
Posted: 2014-12-28
+1
I agree, this is a convincing proof of concept that demonstrates that it is possible to research activity of neuronal connectivity in living organisms. Next steps are likely to bring exciting new insights into brain function Reply


 

Recent headlines

  • Posted in Medicine on 2018-06-22 05:28:13
    New discovery could put the brakes on metastatic cancer..read more
    Posted in Software on 2018-06-21 03:22:47
    IBM Unveils System That 'Debates' With Humans..read more
    Posted in Science on 2018-06-21 03:12:27
    NASA unveils bold new plan to protect Earth from asteroids..read more
    Posted in Science on 2018-06-21 03:03:04
    Machine learning may be a game-changer for climate.....read more
    Posted in Science on 2018-06-20 02:26:18
    Pushing the limit: could cyanobacteria terraform Mars?..read more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in about.....read more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for commercial.....read more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 Downloads..read more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into new.....read more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs,.....read more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for commercial.....read more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short Sighted..read more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, but.....read more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in about.....read more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target mitochondria..read more

Recent Blog Posts

  • Posted by AlexMuller
    In five years quantum computing will be mainstream..read more
    Posted by AlexMuller
    Google partners with Johnson and Johnson to make lower cost.....read more
    Posted by AlexMuller
    Electron holography microscope with spatial resolution down to.....read more
    Posted by AlexMuller
    Lower cost advanced Nuclear power could dominate future US energy..read more
    Posted by AlexMuller
    Why Hasn’t AI Mastered Language Translation?..read more

Login to your Account

Login to your PlanetTech Account here

Username:
Password:
Remember me
or

Create a New Account

You just need username and password

The following errors occured:
Username:
Email:
Password:
Verify password:
Remember me