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Prion like proteins drive several diseases of aging

RATE THIS! +47
Posted in Science on 10th Sep, 2013 01:04 AM by AlexMuller

 Many of the brain diseases associated with aging, such as Alzheimer’s and Parkinson’s, are caused by specific proteins that misfold and aggregate into harmful seeds — similar to what happens with prions.

 

 

 
That’s a new hypothesis that two leading neurology researchers — Mathias Jucker and Lary Walker — have proposed.
 
These seeds behave very much like the pathogenic agents known as prions, which cause mad cow disease, chronic wasting disease in deer, scrapie in sheep, and Creutzfeldt-Jakob disease in humans, the researchers say.
 
The hypothesis could unify scientists’ thinking about several neurodegenerative diseases and suggest therapeutic strategies to combat them.
 
Walker is research professor at Yerkes National Primate Research Center, Emory University. Jucker is head of the Department of Cellular Neurology at the Hertie Institute for Clinical Brain Research at the University of Tübingen and the German Center for Neurodegenerative Diseases.
 
Unlike prion diseases, which can be infectious, Alzheimer’s, Parkinson’s, and other neurodegenerative diseases cannot be passed from person to person under normal circumstances. Once all of these diseases take hold in the brain, however, it is increasingly apparent that the clumps of misfolded proteins spread throughout the nervous system and disrupt its function, the researchers suggest.
 
The two authors of the recent Nature paper where this hypothesis has been proposed were previously the first to show that amyloid-beta, a protein involved in Alzheimer’s disease, forms prion-like seeds that stimulate the aggregation of other amyloid-beta molecules in senile plaques and in brain blood vessels. Since then, a growing number of laboratories worldwide have discovered that proteins linked to other neurodegenerative disorders also share key features with prions.
 
Age-related neurodegenerative disorders remain stubbornly resistant to the discovery of effective treatments. But Jucker and Walker propose that the concept of pathogenic protein seeding could focus research strategies for these seemingly unrelated diseases.


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Comments

Author: Guest
Posted: 2013-09-10
+7
Congratulations to these two and their teams. Apparently at this time though this is just another theory. It would be a good thing if it were true and hopefully through further studies it can be proven so. Keep the work going. Reply
Author: Guest
Posted: 2013-09-10
+7
The fact that is stated in the article that age-related neurodegenerative disorders remain stubbornly resistant to the discovery of effective treatments seems to be true and so many suffer from these disorders. Reply
Author: Guest
Posted: 2013-09-10
+6
The article is saying that there are specific proteins that misfold and aggregate into harmful seeds are the cause for this disorders and this is a hypothesis. (Last time I looked that one up it meant theory) Reply
Author: Guest
Posted: 2013-09-12
+0
yDs22C Really enjoyed this article.Really looking forward to read more. Keep writing. Reply
Author: Guest
Posted: 2013-11-22
+0
Dec25 Good post here. One thing I'd like to say is the fact most professional craeer fields consider the Bachelor Degree just as the entry level requirement for an online certification. Although Associate Degrees are a great way to begin, completing ones Bachelors opens up many opportunities to various employment goodies, there are numerous online Bachelor Course Programs available from institutions like The University of Phoenix, Intercontinental University Online and Kaplan. Another thing is that many brick and mortar institutions make available Online editions of their certifications but normally for a considerably higher cost than the corporations that specialize in online college diploma programs. Reply


 

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