Social Media Sidebar

Announcement

Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

We are all now connected by the Internet, like neurons in a giant brain.

 

Stephen Hawking

 

Probiotic treats diabetes in rats, could lead to human remedy

RATE THIS! +27
Posted in Science on 30th Jan, 2015 03:56 PM by AlexMuller

Imagine a pill that helps people control diabetes with the body’s own insulin to lower blood glucose levels. Cornell researchers have achieved this feat in rats by engineering human lactobacilli, a common gut bacteria, to secrete a protein that modifies intestinal cells to produce insulin.

 
A 2003 study led by Atsushi Suzuki of the University of Tsukuba, Japan, first demonstrated that when exposed to a protein called Glucagon-like peptide 1 (GLP-1), intestinal epithelial cells (which cover the guts) are converted into insulin-producing cells.
 
But until now, it has not been possible to administer GLP-1 into a live animal without injecting it, a method of administration that is not very effective.
 
The researchers came up a clever way to secrete GLP-1 in the gut without injecting it:
 
1. They engineered a strain of lactobacillus, a human probiotic (“good bacteria”), to secrete GLP-1.
 
2. They administered the modified probiotic bacteria orally to diabetic rats for 90 days.
 
3. Upper intestinal epithelial cells in diabetic rats were converted into cells that acted very much like pancreatic cells (cells that monitor blood glucose levels and secrete insulin as needed to balance glucose levels in healthy individuals).
 
4. Rats with high blood glucose (called hyperglycemia, a hallmark of diabetes) that received the engineered probiotic ended up with up to 30 percent lower blood glucose levels.
 
A pill instead of an injection
 
The rat study was a proof of principle; future work will test higher doses to see if a complete treatment can be achieved, said John March, professor of biological and environmental engineering in the College of Agriculture and Life Sciences and the paper’s senior author.

Tags: diabetessugarglucosehealthmedicinebacteria

Read original article » Back to category

Comments

Author: Guest
Posted: 2015-01-31
+1
The links between our gut bacteria and health are at a stage of rapid discoveries and it is not just diabetes but mental illnesses also that show some link and a new potential routes for treatment Reply


 

Recent headlines

  • Posted in Science on 2017-07-27 15:19:10
    Could 'cocktail geoengineering' save the climate?..read more
    Posted in Science on 2017-07-27 15:13:16
    Ketamine has 'truly remarkable' effect on depression..read more
    Posted in Science on 2017-07-27 14:59:50
    Renewable Energy Just Hit a Big Milestone..read more
    Posted in Medicine on 2017-07-26 17:05:11
    Eye test could help diagnose autism..read more
    Posted in Science on 2017-07-26 16:55:24
    Cognitive cross-training enhances learning, study finds..read more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in about.....read more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for commercial.....read more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 Downloads..read more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into new.....read more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs,.....read more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for commercial.....read more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short Sighted..read more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, but.....read more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in about.....read more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target mitochondria..read more

Recent Blog Posts

  • Posted by AlexMuller
    Nanoparticle vaccine shows potential as immunotherapy to fight.....read more
    Posted by AlexMuller
    Obesity is top cause of preventable life-years lost, study shows..read more
    Posted by AlexMuller
    Light can be utilized to control gene function..read more
    Posted by AlexMuller
    Brain stimulation restores memory during lapses, research shows..read more
    Posted by AlexMuller
    Wax worm caterpillar will eat plastic shopping bags: New.....read more

Login to your Account

Login to your PlanetTech Account here

Username:
Password:
Remember me
or

Create a New Account

You just need username and password

The following errors occured:
Username:
Email:
Password:
Verify password:
Remember me