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Progress in Efforts to Develop Lab Grown Lungs: Functional Cells

RATE THIS! +46
Posted in Science on 29th Dec, 2013 01:37 AM by AlexMuller

Since the development of induced pluripotent stem cells in 2006, scientists have managed to use the manufactured stem cells like seeds to grow a wide range of tissues and rudimentary organs. These advances have generated a lot of excitement about future applications.

 

Specifically, the potential to grow new organs for patients rather than requiring them to wait for a transplant.

 
It’s an exciting endpoint, but there are still major hurdles to clear before we get there. Different tissue types have not proven equal, and researchers are still struggling to coax stem cells to take on certain roles, including workhorses like lung cells. But Columbia University researchers recently managed to develop functional lung and airway cells from human iPSCs.
 
In work published in Nature Biotechnology, the researchers developed six types of lung and airway cells and documented evidence of basic functionality.
 
“Researchers have had relative success in turning human stem cells into heart cells, pancreatic beta cells, intestinal cells, liver cells, and nerve cells, raising all sorts of possibilities for regenerative medicine. Now, we are finally able to make lung and airway cells,” said study leader Hans-Willem Snoeck in a news release. “This is important because lung transplants have a particularly poor prognosis.”
 
By removing chemicals that seem to stymie the development of lung cells, Snoeck and his colleagues were able to obtain more lung cells from the stem cells (see photo above). The resulting cells showed evidence of working as they would in the body, with Type 2 aveolar cells absorbing and releasing surfactant, which helps maintain the cells where gas exchange takes place.
 
Solid evidence, in other words, but not a home run.

Tags: stem cellsregenerative medicinebiologyhealthlungsiPSC

Read original article » Back to category

Comments

Author: Guest
Posted: 2013-12-29
+1
Stem cell research is getting closer to delivering new technologies for regenerative medicine. Lung is a critical organ that is affected by many diseases such as cancer and the ability to use stem cells could make a big difference
8 Replies
Author: Guest
Posted: 2013-12-29
+1
This needs to be put into perspective. Any clinical application of this lung stem cell research is still many years away. Scientists believe that we will have implantable organs but it will be at least several more decades before they are available Reply
Author: Guest
Posted: 2013-12-29
+0
This seems to be the case and many aspects of regenerative medicine are still to be perfected before any human trials start Reply
Author: Guest
Posted: 2013-12-29
+0
Efforts to create organs will benefit from building 3D printers. But it will be a long slog to get to custom-made organs.
Reply
Author: Guest
Posted: 2013-12-29
+0
Bioprinting should be supported- bioprinting efforts are ongoing, funding is coming and there are already companies established based on this idea. 3D printing is already known in cardiovascular innovation. Branched vessel structures can be generated by Inkjet printing technology.
 Reply
Author: Guest
Posted: 2013-12-29
+0
The principle of 3D printing has been around for more than a decade, and is already used successfully to create jewellery, toys, furniture or cars- it is now time for bioprinters! Reply
Author: Guest
Posted: 2013-12-29
+0
Yes, but printing biomaterial is an entirely different ball game - this is a big deal Reply
Reply
Author: Guest
Posted: 2013-12-29
+0
Great news. We hope for more progress in regeneration and reconstruction of the lung so that we bring this to reality sooner then some decades Reply
Author: Guest
Posted: 2013-12-29
+1
Regenerative medicine is the key. The future of medicine lies in understanding how the body creates itself out of a single cell and the mechanisms by which it renews itself throughout life.
3 Replies
Author: Guest
Posted: 2013-12-29
+1
Yes, we hope that one day it will be possible to replace damaged tissues and help the body regenerate itself, potentially curing or easing the suffering of those afflicted by disorders like heart disease, Alzheimers, Parkinsons, diabetes, spinal cord injury and cancer. Reply
Author: Guest
Posted: 2013-12-29
+0
And that the efforts and successes could be exponential! Reply
Reply
Author: Guest
Posted: 2013-12-29
+0
A good progress is made with other organs but also limitations remain serious. Recently, researchers crafted a heart that beat, but it didn’t beat with enough power or synchronization to sustain a life.
2 Replies
Author: Guest
Posted: 2013-12-29
+0
Yes, recently researchers have announced that they have grown a rudimentary kidney in the laboratory using human stem cells, which may give more treatment options to those with renal disease. Reply
Reply


 

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