Social Media Sidebar


Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

When seen through the lens of technology, few resources are truly scarce; they’re mainly inaccessible. 


Peter Diamandis

Promising results for new Alzheimer's therapy

Posted in Science on 14th Feb, 2015 08:18 PM by AlexMuller

Karolinska Institute has evaluated a new Alzheimer's therapy in which the patients receive an implant that stimulates the growth of a certain type of nerve cell. The results, which are published in the scientific journal Alzheimer's & Dementia, suggest that the introduction of a nerve growth factor can prevent neuronal degradation in patients.

Patients with Alzheimer's disease suffer a selective and early breakdown of so called cholinergic nerve cells, which require a specific nerve growth factor (NGF), essentially a group of proteins necessary for cell growth and survival, to function. As NGF levels decline, the cholinergic nerve cells begin to degrade and the patient's condition slowly deteriorates.
In an attempt to curb the breakdown of the cholinergic nerve cells, researchers at Karolinska Institutet's Centre for Alzheimer's Research and their colleagues at Karolinska University Hospital's neurosurgery clinic and the Danish biotech company NsGene introduced NGF directly into the brains of Alzheimer's patients.
To do this, they used NGF-producing cell capsules, placing them in the basal fore-brain where the cholinergic cells reside using precision stereotactic surgery. There the capsules, which can easily be removed, release NGF to the surrounding cells in order to prevent their degradation.
The study now published in Alzheimer's & Dementia is based on data from six Alzheimer's patients. To gauge whether the NGF release had any effect on the cholinergic nerve cells, the researchers assayed the presence of specific markers of functioning cholinergic cells.
This cell system communicates using acetylcholine, which in turn produces an enzyme called ChAT (pronounced Cat) that is found both inside and outside the cells. The team therefore developed a method enabling them to measure ChAT in the cerebral spinal fluid for the first time.
"Our results show that when the patients received NGF, there was a significant increase in ChAT in the CSF," says Dr Taher Darreh-Shori, one of the researchers involved in the study. "The patients that exhibited this increase were also those that responded best to the treatment. Our PET scans also showed an increase in cholinergic cell activity and metabolism in the brain."

Tags: brainneuroscienceAlzheimer'sdementiaaginghealthmedicine

Read original article » Back to category


Author: Guest
Posted: 2015-02-15
It is good to see that new potential treatments for neurodegenerative diseases are coming and it is now a matter of time to establish which of those will be suitable for the clinic Reply


Recent headlines

  • Posted in Software on 2018-03-16 11:03:28
    60.3% of harmful Android apps in 2017 detected more
    Posted in Hardware on 2018-03-16 11:00:28
    Big harpoon is 'solution to space junk' more
    Posted in Science on 2018-03-16 10:58:40
    Russia will beat NASA to mars and find water on the moon, more
    Posted in Business on 2018-03-14 07:02:30
    X Prize announces $10 million competition to more
    Posted in Business on 2018-03-14 06:57:20
    How to spot a cryptocurrency more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs, more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target more

Recent Blog Posts

  • Posted by AlexMuller
    Martian landscapes formed from sand 'levitating' on a more
    Posted by AlexMuller
    Scientists detect comets outside our solar more
    Posted by AlexMuller
    Advanced artificial limbs mapped in the more
    Posted by AlexMuller
    Bacteria have a sense of more
    Posted by AlexMuller
    Recurrent brain cancer: New hope with phase 1 clinical more

Login to your Account

Login to your PlanetTech Account here

Remember me

Create a New Account

You just need username and password

The following errors occured:
Verify password:
Remember me