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Repeated Oral doses of C60 fullerene increased the lifespan of rats by 60 to 73% in a small study

RATE THIS! +1
Posted in Science on 19th Apr, 2012 04:06 AM by AlexMuller

Countless studies showed that [60]fullerene (C60) and derivatives could have many potential biomedical applications. However, while several independent research groups showed that C60 has no acute or subacute toxicity in various experimental models, more than 25 years after its discovery the in vivo fate and the chronic effects of this fullerene remain unknown. If the potential of C60 and derivatives in the biomedical field have to be fulfilled these issues must be addressed. Here we show that oral administration of C60 dissolved in olive oil (0.8 mg/ml) at reiterated doses (1.7 mg/kg of body weight) to rats not only does not entail chronic toxicity but it almost doubles their lifespan. The effects of C60-olive oil solutions in an experimental model of CCl4 intoxication in rat strongly suggest that the effect on lifespan is mainly due to the attenuation of age-associated increases in oxidative stress. Pharmacokinetic studies show that dissolved C60 is absorbed by the gastro-intestinal tract and eliminated in a few tens of hours. These results of importance in the fields of medicine and toxicology should open the way for the many possible -and waited for- biomedical applications of C60 including cancer therapy, neurodegenerative disorders, and ageing.

 

The results of this pharmacokinetic study show for the first time that C60 is absorbed by the gastro-intestinal tract. In the case of oily solutions, the drug release rate is controlled by the partition coefficient of the drug between the oily vehicle and the tissue fluid and lipophilic drugs may be released concurrently with the disappearance of the oily vehicle from the injection site.

 

Four possible mechanisms for C60-liver protection were proposed:
(1) C60 can scavenge large numbers of free radicals
(2) it can act as a decomposition catalyst for O2/H2O2, as it has been postulated for its tris-malonic acid derivatives
(3) as a cytochrome P450 inhibitor as it has been reported for some fullerene derivatives
(4) it can inactivate Kupffer cells (liver resident macrophages) through accumulation and overloading with a large number of C60 aggregates

 

Pathological examinations show that even at very low doses, 500 times lower than that used previously, C60-olive oil solutions effectively protects the livers against CCl4 toxicity. These results are in agreement with those reported for very low doses of water solution of hydrated C60 fullerene in other experimental models.

 

The effect of pristine C60 on lifespan emphasizes the absence of chronic toxicity. These results obtained with a small sample of animals with an exploratory protocol ask for a more extensive studies to optimize the intestinal absorption of C60 as well as the different parameters of the administration protocol: dose, posology and treatment duration. In the present case, the treatment was stopped when a control rat died at M17, which proves that the effects of the C60 treatment are long-lasting as the estimated median lifespan for C60-treated rats is 42 months. It can be thought that a longer treatment could have generated even longer lifespans. Anyway, this work should open the road towards the development of the considerable potential of C60 in the biomedical field, including cancer therapy, neurodegenerative disorders and ageing. Furthermore, in the field of ageing, as C60 can be administered orally and as it is now produced in tons, it is no longer necessary to resort to its water-soluble derivatives, which are difficult to purify and in contrast to pristine C60 may be toxic.

 



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Comments

Author: Guest
Posted: 2012-09-07
+0
Jun06 Alles Liebe und Gute ffcr euch. Ich drfccke die Daumen! Es gibt nichts sennnpaderes als ein bevorstehende Geburt, herrlich!Viele Grfcdfe!Renata & family Reply
Author: Guest
Posted: 2012-11-16
+0
I've taken C60 in Extra Virgin Olive Oil for 3 months and have no adverse effects. Oh...many of us are already taking it. I'll explain it to you in about...say....100 years or so. Reply
Author: Guest
Posted: 2013-08-05
+0
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Author: Guest
Posted: 2013-09-06
+0
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Author: Guest
Posted: 2013-09-13
+0
stGH0N Thanks so much for the post. Cool. Reply
Author: Guest
Posted: 2013-09-24
+0
bLWrLS A round of applause for your blog.Thanks Again. Really Cool. Reply
Author: Guest
Posted: 2013-10-16
+0
zUB1sL Wow, great blog post. Fantastic. Reply
Author: Guest
Posted: 2013-10-24
+0
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Author: Guest
Posted: 2013-11-01
+0
85dTsI Major thanks for the blog.Really looking forward to read more. Much obliged. Reply
Author: Guest
Posted: 2014-01-08
+0
WZjL0J I really enjoy the blog article.Thanks Again. Much obliged. Reply
Author: Guest
Posted: 2014-01-31
+0
dNSOqQ Thanks so much for the article.Really thank you! Really Great. Reply
Author: Guest
Posted: 2014-04-18
+0
TVl2ep Awesome article post.Much thanks again. Will read on... Reply
Author: Guest
Posted: 2014-06-07
+0
New Balance Styles For Kids on The Go, Why would a kid need a pair of athletic shoes? The founder of New Balance, William Riley, would have probably posed the same question,When he started his company in 1906, they manufactured arch supports and orthopedic shoes for adults with bad feet,In fact, the company was originally called the New Balance Arch Co,The small shoemaker out of Belmont, Massachusetts rarely turned a profit in its first half century of existence,It wasn't until they produced a running shoe called the "Trackster" in 1960 that balancing the books became a reality,The timing couldn't have been more perfect,For some strange, unexplained reason, running had suddenly become one of the fastest growing recreational activities in the United States,New Balance first caught on with high school and college track coaches, who often purchased specialty shoes for their entire teams,Because the company eschewed advertising of any kind, they depended on wordofmouth marketing,It wasn't until Tom Fleming won the 1975 Boston Marathon in a pair of New Balance 320s that the company became an overnight success, nearly seven decades in the making,Bolstered by commercial and critical acclaim, the company invested in their new athletic division,Shortly thereafter, they changed their name to New Balance Athletic Shoes, Inc,Their targe Reply
Author: Guest
Posted: 2014-07-13
+0
Wow, what a spamfest! If people want to know about the use of c60-olive oil in humans, they can find a great deal of discussion at Longecity dot org. See the "C60Health" forum under the "nanotech" forum. Reply
Author: Guest
Posted: 2014-11-30
+0
したとて意味がない。先夜の捕物のことは市中に広まった。さて……どうすればいいものか」平蔵は舌打ちして仙波を見詰めた。仙波はただ平伏するしかなかった。それを考えるのは頭の仕事であって仙波が口を Reply
Author: Guest
Posted: 2015-01-13
+0
しまう。吉田順吉に電話をかけ、「あれ、新聞で見たよ」と、耕平は祝意を表したが、「ああ、H氏賞か。こっちには関係無いな」と、吉田はいつもながらの面倒くさそうな口調であった。「しかし、受賞%8 Reply
Author: Guest
Posted: 2015-01-19
+0
帰るというのは変ですな……旦那は、だいぶご酒がいけますな」「さよう……たんともいかんけれど、朝一升、昼一升、夕べに一升、寝酒に一升だな」「へーえ、一日に四升! ずいぶんめしあがりますな」「そのほうは飲めんか%b Reply
Author: Guest
Posted: 2015-03-18
+0
Just about all of whatever you say happens to be astonishingly accurate and that makes me ponder why I had not looked at this in this light previously. This particular piece truly did switch the light on for me personally as far as this specific issue goes. But there is actually one point I am not necessarily too cozy with and whilst I try to reconcile that with the main idea of your issue, permit me Reply
Author: Guest
Posted: 2015-06-11
+0
IYNbdw wow, awesome post.Much thanks again. Keep writing. Reply
Author: Guest
Posted: 2015-10-16
+0
fddi0Y Really enjoyed this post. Will read on... Reply


 

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