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Researchers grow human kidney using stem cells

RATE THIS! +52
Posted in Science on 18th Dec, 2013 02:48 AM by AlexMuller

Around 2% of all adults experience kidney disease, and which results in tens of thousands of deaths each year. Only 25% of those on the wait list for a donor kidney will ever receive the lifesaving call.

 

Researchers have announced that they have grown a rudimentary kidney in the laboratory using human stem cells, which may give more treatment options to those with renal disease. The paper was published in Nature Cell Biology by Melissa Little from the University of Queensland's Institute for Molecular Bioscience.

 
The kidney is an organ in the urinary system which is used to ensure homeostasis in the body by regulating electrolytes, pH of the body, and even blood pressure. It is built from two different stem cell types. The team working in Little’s lab originally meant to create one kind, but was very surprised to discover that both cells had been created.
 
As the cells began to grow and proliferate, they assembled themselves into a miniature human kidney. The team used specific growth factors along with information about normal embryological development in order to guide the cells toward the intended complete organ.
 
Earlier this year, an American team announced that they had created a rat kidney from stem cells, though it was incredibly inefficient when transplanted into an organism. This organ from Little’s lab was created with human stem cells and can give researchers an unprecedented insight into how new medications will impact human kidneys, which can dramatically improve success in clinical safety trials. They also represent the potential for improved treatment of renal disease, as that is an area that is lacking at present.
 
For those who are suffering renal disease, dialysis and organ transplantation are the two main treatments available. Eventually, decades down the road, this technology could potentially be used to create full-sized replacement organs for those who have exhausted all other options.

Tags: kidneyhealthregenerative medicinestem cellsorgan transplant

Read original article » Back to category

Comments

Author: Guest
Posted: 2013-12-18
+2
Availability of organs and compatibility with donors are bottleneck for transplantation. Regeneration and organ production would solve this huge problem
4 Replies
Author: Guest
Posted: 2013-12-18
+0
Bioprinting should be supported- bioprinting efforts are ongoing, funding is coming and there are already companies established based on this idea.
3 Replies
Author: Guest
Posted: 2013-12-18
+0
Yes, Organovo is one of the firms pioneering the use of printed live structures for medical purposes Reply
Author: Guest
Posted: 2013-12-18
+0
There is some funding. Critical illnesses can already be successfully treated today by replacing cells, tissue or organs. Government, industry and the research establishment have therefore been working hard to improve methods and procedures for artificially producing tissue. Reply
Reply
Author: Guest
Posted: 2013-12-18
+0
3D printing is already known in cardiovascular innovation. Branched vessel structures can be generated by Inkjet printing technology.
 Reply
Reply
Author: Guest
Posted: 2013-12-18
+1
The principle of 3D printing has been around for more than a decade, and is already used successfully to create jewellery, toys, furniture or cars- it is now time for bioprinters!
1 Replies
Author: Guest
Posted: 2013-12-18
+0
Yes, but printing biomaterial is an entirely different ball game - this is a big deal Reply
Reply


 

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