Social Media Sidebar


Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

Just because something doesn’t do what you planned it to do doesn’t mean it’s useless.


Thomas Edison

Sadness-induced inflammation linked to comorbid diseases

Posted in Science on 21st Dec, 2015 06:43 PM by AlexMuller

Feeling sad can alter levels of stress-related opioids in the brain and increase levels of inflammatory proteins in the blood that are linked to increased risk of comorbid diseases including heart disease, stroke and metabolic syndrome, according to a study by researchers at The University of Texas Health Science Center.

Previous studies have shown that major depression can be a contributing factor to other medical diseases, but researchers didn't know why. A team led by Alan Prossin, M.B.B.S., assistant professor in the Department of Psychiatry and Behavioral Sciences at the John P. and Kathrine G. McGovern Medical School, sought to find the answer.
When a person is under stress, brain neurotransmitters called opioids are released to reduce the impact of stress, said Prossin, the study's principal investigator. But when this stress response system is dysregulated, opioid neurotransmitters may have a negative impact on the body, altering the immune system response to stress, potentially increasing risk of other medical diseases.
Research subjects, both people suffering from a major depressive disorder and healthy controls, underwent positron emission tomography (PET) scans during the study, starting with a baseline scan. At baseline, depressed patients showed more opioid activity (and greater IL-18 concentration in the blood) than the healthy controls.
When asked to think about something neutral, opioid activity decreased in the brains of both groups and the opioid decrease was proportional to a decrease in IL-18 in the same people.
When asked to focus on the sadness they experienced during a sad event in their life, increased amounts of opioids were released in the brain and this opioid increase was proportional to increased IL-18 concentration in the blood.
"These effects were observed during sadness in both groups, but were much greater in people with major depression as compared to non-depressed, otherwise healthy people," Prossin said.
In the depressed group, following sadness, the level of IL-18 had increased, but not to the baseline concentration. In other words, thinking neutral thoughts had a lowering effect on IL-18 that persisted even after the same people were asked to think about sad things.
"Inducing a neutral affective state improved mood and lowered IL-18," Prossin said. "So if we could implement psychotherapies to improve mood in depressed people, then we could potentially normalize IL-18 and in the longer term, potentially reduce risk of various comorbid medical illnesses."
"This is potentially a new pathway associated with stress-related affective changes that could explain why treatments based on classic stress hormones may not be as effective in depressed people with stress-related mood changes," Prossin said.

Tags: bloodhealthmedicinepsychologybraininflammation

Read original article » Back to category



Recent headlines

  • Posted in Medicine on 2018-05-23 01:38:21
    UCLA engineer develops 3D printer that can create more
    Posted in Business on 2018-05-23 01:43:09
    China Launches Satellite Bound for the Far Side of the more
    Posted in Business on 2018-05-21 16:28:10
    Anti-nuclear policies increased global carbon by more
    Posted in Medicine on 2018-05-21 16:22:31
    Magic mushroom treatment improves emotional more
    Posted in Medicine on 2018-05-21 16:18:57
    Antioxidant found to wind back the clock on blood more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs, more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target more

Recent Blog Posts

  • Posted by AlexMuller
    In five years quantum computing will be more
    Posted by AlexMuller
    Google partners with Johnson and Johnson to make lower more
    Posted by AlexMuller
    Electron holography microscope with spatial resolution down more
    Posted by AlexMuller
    Lower cost advanced Nuclear power could dominate future US more
    Posted by AlexMuller
    Why Hasn’t AI Mastered Language Translation? more

Login to your Account

Login to your PlanetTech Account here

Remember me

Create a New Account

You just need username and password

The following errors occured:
Verify password:
Remember me