Social Media Sidebar

Announcement

Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

People say we're running out of energy. That's only true if we stick with these old 19th century technologies. We are awash in energy from sunlight.

 

Ray Kurzweil

 

Scientists develop 'game changing' stem cell repair system

RATE THIS! +54
Posted in Science on 5th Apr, 2016 11:24 AM by AlexMuller

The repair system, similar to the method used by salamanders to regenerate limbs, could be used to repair everything from spinal discs to bone fractures, and has the potential to transform regenerative medicine. The research has been published in the Proceedings of the National Academy of Sciences journal.

 

Study lead author, haematologist and UNSW Associate Professor John Pimanda, said the new technique, which reprograms bone and fat cells into induced multipotent stem cells (iMS), has been successfully demonstrated in mice.
 
"We are currently assessing whether adult human fat cells reprogrammed into iMS cells can safely repair damaged tissue in mice, with human trials expected to begin in late 2017."
 
There are different types of stem cells including embryonic stem (ES) cells, which during embryonic development generate every type of cell in the human body, and adult stem cells, which are tissue-specific. There are no adult stem cells that regenerate multiple tissue types.
 
"This technique is ground-breaking because iMS cells regenerate multiple tissue types," Associate Professor Pimanda said.
 
"We have taken bone and fat cells, switched off their memory and converted them into stem cells so they can repair different cell types once they are put back inside the body."
 
The technique developed by UNSW researchers involves extracting adult human fat cells and treating them with the compound 5-Azacytidine (AZA), along with platelet-derived growth factor-AB (PDGF-AB) for approximately two days. The cells are then treated with the growth factor alone for a further two-three weeks.
 
The new technique is similar to salamander limb regeneration, which is also dependent on the plasticity of differentiated cells, which can repair multiple tissue types, depending on which body part needs replacing.
 
"Embryonic stem cells cannot be used to treat damaged tissues because of their tumour forming capacity. The other problem when generating stem cells is the requirement to use viruses to transform cells into stem cells, which is clinically unacceptable," Dr Chandrakanthan said. "We believe we've overcome these issues with this new technique."
 
Neurosurgeon and Conjoint Lecturer with UNSW's Prince of Wales Clinical School, Dr Ralph Mobbs, will lead the human trials, once the safety and effectiveness of the technique using human cells in mice has been demonstrated.
 
"The therapy has enormous potential for treating back and neck pain, spinal disc injury, joint and muscle degeneration and could also speed up recovery following complex surgeries where bones and joints need to integrate with the body," Dr Mobbs said.
 
Research shows that up to 20% of spinal implants either don't heal or there is delayed healing. The rates are higher for smokers, older people and patients with diseases such diabetes or kidney disease.
 
"Spinal implants currently used to replace damaged or troubled discs don't always weld with the adjacent bones, so by transplanting these reprogrammed stem cells, we hope to be able to better fuse these implants to the host bone," Dr Mobbs said.
 
"This represents a potential huge leap forward for spinal and orthopaedic procedures."
 
Along with confirming that human adult fat cells reprogrammed into iMS stem cells can safely repair damaged tissue in mice, the researchers said further work is required to establish whether iMS cells remain dormant at the sites of transplantation and retain their capacity to proliferate on demand.

Tags: medicineresearchstem cellsbiotechnologyregenerative medicine

Read original article » Back to category

Comments

Author: Guest
Posted: 2016-04-06
+1
Very interesting! After decades of research on salamander limb regenerations, stem cell procedures that would help humans are finally on the horizon
1 Replies
Author: Guest
Posted: 2016-04-06
+0
Regenerative medicine is showing a great prospect and will bring new options for reconstituted organs and hopefully facilitate transplantation Reply
Reply


 

Recent headlines

  • Posted in Science on 2017-10-22 04:22:31
    Blue Origin’s Breakthrough Means SpaceX Finally Has a.....read more
    Posted in Business on 2017-10-22 04:17:51
    Bitcoin boom prompts growth of coin-mining malware..read more
    Posted in Science on 2017-10-22 04:14:04
    MDMA Advances Another Step As Tool to Treat PTSD..read more
    Posted in Science on 2017-10-21 02:03:22
    Japan Just Discovered the Perfect Spot to Build a Moonbase..read more
    Posted in Hardware on 2017-10-21 01:52:51
    Up to 200 pound pieces of China’s Space Station could.....read more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in about.....read more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for commercial.....read more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 Downloads..read more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into new.....read more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs,.....read more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for commercial.....read more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short Sighted..read more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, but.....read more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in about.....read more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target mitochondria..read more

Recent Blog Posts

  • Posted by AlexMuller
    Scientists probe Neptune's depths to reveal secrets of icy.....read more
    Posted by AlexMuller
    New terahertz imaging approach could speed up skin cancer.....read more
    Posted by AlexMuller
    Rebutting the claim that antidepressants do not work..read more
    Posted by AlexMuller
    Artificial neural networks decode brain activity during.....read more
    Posted by AlexMuller
    Four Earth-sized planets detected orbiting the nearest.....read more

Login to your Account

Login to your PlanetTech Account here

Username:
Password:
Remember me
or

Create a New Account

You just need username and password

The following errors occured:
Username:
Email:
Password:
Verify password:
Remember me