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Quote of the day

'By far the greatest danger of Artificial Intelligence is that people conclude too early that they understand it'

 

Eliezer Yudkowsky

Scientists Get Closer to Rejuvenating Aging Muscles

RATE THIS! +36
Posted in Science on 19th Feb, 2014 02:58 AM by AlexMuller

As millions of aging Baby Boomers know, muscle tone and strength declines with advancing age, regardless of gym workouts. Now scientists say they might have uncovered a clue as to why that happens, and new cell targets to help reverse it.

 

In studies in aging mice, researchers at Stanford University found that, over time, the stem cells that help repair damaged muscle cells after injury are less able to do so.

 
This helps explain why regaining strength and recovering from a muscle injury gets more difficult with age, the researchers said in work published online Feb. 16 in the journal Nature Medicine.
 
But there was good news too: The study might also point to a way to make older muscle stem cells function more like younger ones. But research in mice often doesn't translate to humans, so the researchers stressed that more study is needed to determine if this technique could ever be used in people.
 
"In the past, it's been thought that muscle stem cells themselves don't change with age, and that any loss of function is primarily due to external factors in the cells' environment," study senior author Helen Blau, director of Stanford's Baxter Laboratory for Stem Cell Biology, said in a university news release.
 
"However, when we isolated stem cells from older mice, we found that they exhibit profound changes with age," said Blau, a professor of microbiology and immunology at the university. "Two-thirds of the cells are dysfunctional when compared to those from younger mice, and the defect persists even when transplanted into young muscles."
 
The research also revealed, however, that there is a defect specific to old muscle stem cells that can be corrected, allowing scientists to rejuvenate the cells.
 
"Most exciting is that we also discovered a way to overcome the defect," Blau said. "As a result, we have a new therapeutic target that could one day be used to help elderly human patients repair muscle damage."

Tags: healthageingmusclestrengthmedicinestem cells

Read original article » Back to category

Comments

Author: Guest
Posted: 2014-02-19
+3
I hope that this research is not in any way linked to cosmetics- this is about staying healthier for longer
4 Replies
Author: Guest
Posted: 2014-02-19
+2
Sure, this really is a new way to enhance the repair of specific muscles in the elderly, especially after an injury
3 Replies
Author: Guest
Posted: 2014-02-19
+1
Yes, the aim is to develop an anti-ageing therapy that could have a dramatic impact on public health by reducing the burden of age-related health problems, such as dementia, stroke and heart disease, and prolonging the quality of life for an increasingly aged population Reply
Author: Guest
Posted: 2014-02-19
+0
Whether this discovery and potential treatment means we’ll all live to 150, is not so important, but the important part is that we don’t spend the last 20 to 30 years of our lives in bad health. Reply
Reply
Author: Guest
Posted: 2014-02-19
+0
I agree. The key question is what might this mean for human therapies against age-related diseases? Reply
Author: Guest
Posted: 2014-02-19
+1
It remains important to continue research. The ageing process is poorly understood, but scientists know it is caused by many factors. Highly reactive particles called free radicals are made naturally in the body and cause damage to cells, while smoking, ultraviolet light and other environmental factors contribute to ageing. We need to understand better these different causes Reply
Author: Guest
Posted: 2014-02-19
+0
Lifestyle should stay in focus. Some time ago we had a study that showed that just pottering around the garden or fixing up the house has been linked to a longer life in people over the age of 60. Reply
Reply
Author: Guest
Posted: 2014-02-19
+2
Indeed what is needed to make progress in understanding ageing and related diseases is more basic research that will have big impact as this one here- great work Reply
Author: Guest
Posted: 2016-05-07
+0
I'm so glad that the inrnteet allows free info like this! Reply


 

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