Social Media Sidebar


Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

Just because something doesn’t do what you planned it to do doesn’t mean it’s useless.


Thomas Edison

Scientists uncover potential biomarker and drug target for autism

Posted in Science on 24th Sep, 2015 06:18 PM by AlexMuller

Improving our understanding of what causes autism spectrum disorder (ASD) can lead to better drugs and more precise methods of diagnosis. As it stands there are no reliable biomarkers for ASD, with previous research implicating hundreds of genes in the condition.


But now a team of scientists has zeroed in on defects in a particular signaling pathway that may be responsible for cognitive impairments associated with the condition.

Though hundreds of different genes are known to be associated with ASD, many of these have also been found to be part of the same signaling pathway. This has lead scientists to believe that multiple defects along this pathway may combine to bring about significant functional change.
Studying the skin biopsies of patients with three different forms of ASD, scientists from the University of California, Irvine (UCI) have discovered this convergence of defects in the calcium signaling channel in the endoplasmic reticulum (ER). The ER belongs to a group of specialized membrane structures within cells called organelles.
As calcium is used to carry information between neurons in the brain, along with activating other cell functions such as regulating learning, memory and others associated with ASD, the scientists say that the defected pathway represents a possible reliable biomarker for diagnosing the condition.
"We propose that the proper function of this channel and its signaling pathway is critical for normal performance of neurons and that this signaling pathway represents a key 'hub' in the pathogenesis of ASD," says Dr Ian Parker from the UCI Center for Autism Research & Translation.
The pathway is called the inositol trisphosphate receptor (IP3R) and the researchers are now working to establish whether or not these defects are present across the entire autism spectrum, which means expanding the study to examine more children with and without typical ASD. This will involve behavioral testing, sleep, EEG, biochemical testing and the sequencing of their entire genomes.

Tags: Autismbrainpsychologyhealthdiagnosismedicinegenetics

Read original article » Back to category


Author: Guest
Posted: 2015-09-25
This is what many were waiting for! Now efforts can be focused on some potential targets and hope that these can be confirmed as well as used for developments of treatments
1 Replies
Author: Guest
Posted: 2015-09-25
Indeed, very important step forward! Reply


Recent headlines

  • Posted in Business on 2018-05-21 16:28:10
    Anti-nuclear policies increased global carbon by more
    Posted in Medicine on 2018-05-21 16:22:31
    Magic mushroom treatment improves emotional more
    Posted in Medicine on 2018-05-21 16:18:57
    Antioxidant found to wind back the clock on blood more
    Posted in Software on 2018-05-21 16:14:32
    3 key artificial intelligence benefits for the future more
    Posted in Medicine on 2018-05-20 11:05:43
    Cannabidiol significantly reduces seizures in more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs, more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target more

Recent Blog Posts

  • Posted by AlexMuller
    In five years quantum computing will be more
    Posted by AlexMuller
    Google partners with Johnson and Johnson to make lower more
    Posted by AlexMuller
    Electron holography microscope with spatial resolution down more
    Posted by AlexMuller
    Lower cost advanced Nuclear power could dominate future US more
    Posted by AlexMuller
    Why Hasn’t AI Mastered Language Translation? more

Login to your Account

Login to your PlanetTech Account here

Remember me

Create a New Account

You just need username and password

The following errors occured:
Verify password:
Remember me