Social Media Sidebar

Announcement

Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

'By far the greatest danger of Artificial Intelligence is that people conclude too early that they understand it'

 

Eliezer Yudkowsky

Sequencing the Connectome

RATE THIS! +6
Posted in Science on 25th Oct, 2012 09:47 PM by AlexMuller

A team of neuroscientists led by Professor Anthony Zador, Ph.D., of Cold Spring Harbor Laboratory have proposed a revolutionary new way to create a connectivity map (“connectome”) of the whole brain of the mouse at the resolution of single neurons: high-throughput DNA sequencing.

 

The only current method for obtaining the connectome with high precision relies on laboriously examining individual cell-to-cell contacts (synapses) in electron microscopes, which is slow, expensive and labor-intensive. (See A circuit diagram of the mouse brain.)

 

This reconstruction of serial electron micrographs has yielded what to date is the only complete connectome, that of C. elegans (a nemotode or roundworm). However, even for this simple nervous system, the reconstruction required a heroic effort — more than 50 person-years of labor to collect and analyze the images.

 

The appeal of using sequencing is that its scale and speed — sequencing billions of nucleotides per day is now routine — is a natural match to the complexity of neural circuits. And it’s getting faster exponentially.

 

An inexpensive high-throughput technique for establishing circuit connectivity at single neuron resolution could transform neuroscience research, the open-access PLoS Biology paper says.



Read original article » Back to category

Comments

Author: Guest
Posted: 2012-11-08
+0
I love these articles. How many words can a wordismth smith? Reply


 

Recent headlines

  • Posted in Science on 2017-04-23 16:03:05
    Google's universal quantum computer could become world's.....read more
    Posted in Medicine on 2017-04-23 15:51:27
    Anti-dementia drugs will soon start clinical trials..read more
    Posted in Business on 2017-04-23 15:47:18
    Robots can handle a third of our workplace tasks, study.....read more
    Posted in Science on 2017-04-22 15:31:01
    Proposed Mission to find life on Saturn’s moon Enceladus..read more
    Posted in Medicine on 2017-04-22 14:32:54
    Global plan to wipe out hepatitis..read more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in about.....read more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for commercial.....read more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 Downloads..read more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into new.....read more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs,.....read more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for commercial.....read more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short Sighted..read more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, but.....read more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in about.....read more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target mitochondria..read more

Recent Blog Posts

  • Posted by AlexMuller
    Intensive medical treatment can reverse type 2 diabetes..read more
    Posted by AlexMuller
    Daily consumption of tea protects the elderly from cognitive.....read more
    Posted by AlexMuller
    New analysis method of metabolites accurately predicts whether.....read more
    Posted by AlexMuller
    Unproven stem cell 'therapy' blinds three patients at Florida.....read more
    Posted by AlexMuller
    Indigenous South American group has healthiest arteries of all.....read more

Login to your Account

Login to your PlanetTech Account here

Username:
Password:
Remember me
or

Create a New Account

You just need username and password

The following errors occured:
Username:
Email:
Password:
Verify password:
Remember me