Social Media Sidebar

Announcement

Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

Just because something doesn’t do what you planned it to do doesn’t mean it’s useless.

 

Thomas Edison

Small Molecule Successfully Targets Telomerase to Destroy Cancer Cells

RATE THIS! +35
Posted in Science on 10th Jan, 2015 10:53 PM by AlexMuller

Scientists report that they have targeted telomeres with a small molecule called 6-thiodG that takes advantage of the cell's biological clock to kill cancer cells and shrink tumor growth. 6-thio-2-deoxyguanosine could stop the growth of cancer cells in culture and decrease the growth of tumors in mice.

 
Drs. Shay and Wright are co-senior authors of the study “Induction of Telomere Dysfunction Mediated by the Telomerase Substrate Precursor 6-Thio-2′-Deoxyguanosine” appearing in Cancer Discovery. “Treatment with 6-thio-dG resulted in rapid cell death for the vast majority of the cancer cell lines tested, whereas normal human fibroblasts and human colonic epithelial cells were largely unaffected,” wrote the investigators.
 
“In A549 lung cancer cell–based mouse xenograft studies, 6-thio-dG caused a decrease in the tumor growth rate superior to that observed with 6-thioguanine treatment. In addition, 6-thio-dG increased telomere dysfunction in tumor cells in vivo. These results indicate that 6-thio-dG may provide a new telomere-addressed telomerase-dependent anticancer approach.
 
"We observed broad efficacy against a range of cancer cell lines with very low concentrations of 6-thiodG, as well as tumor burden shrinkage in mice," noted Dr. Shay, who is also associate director of the Harold C. Simmons Comprehensive Cancer Center. Cancer cells are protected from apoptosis by telomerase, which ensures that telomeres do not shorten with every division. Telomerase has therefore been the subject of intense research as a target for cancer therapy.
 
Drugs that successfully block its action have been developed, but these drugs have to be administered for long periods of time to successfully trigger cell death and shrink tumors, leading to considerable toxicities. This outcome is partially because cells in any one tumor have chromosomes with different telomere lengths and any one cell's telomeres must be critically shortened to induce death.

Tags: cancercellstumortelomeregenesgeneticsmedicine

Read original article » Back to category

Comments

Author: Guest
Posted: 2015-01-11
+1
Indeed, one of the hallmarks of cancer cells is that their telomeres are not shortened after each cell division and they appear "immortal". Developing a small molecule drug that can specifically and efficiently target cancer cell by exploiting this phenomenon is an important advance Reply
Author: Guest
Posted: 2015-01-11
+0
Yes, this is a good start. However, many observations using cell culture and animal models never make it clinical trials- success in these is critical to show before we are justifiably hopeful Reply


 

Recent headlines

  • Posted in Business on 2018-04-23 23:22:30
    Climate change: Michael Bloomberg pledges $4.5m for Paris.....read more
    Posted in Medicine on 2018-04-23 23:17:24
    The foods that might help with dementia..read more
    Posted in Hardware on 2018-04-22 23:49:35
    NASA’s proposed multi-billion orbiting moonbase used to.....read more
    Posted in Business on 2018-04-22 23:43:36
    Sunshine State Is Set to Get More Solar After Florida Ruling..read more
    Posted in Medicine on 2018-04-22 23:36:57
    FDA approves first contact lens that gets darker in sunlight..read more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in about.....read more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for commercial.....read more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 Downloads..read more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into new.....read more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs,.....read more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for commercial.....read more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short Sighted..read more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, but.....read more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in about.....read more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target mitochondria..read more

Recent Blog Posts

  • Posted by AlexMuller
    In five years quantum computing will be mainstream..read more
    Posted by AlexMuller
    Google partners with Johnson and Johnson to make lower cost.....read more
    Posted by AlexMuller
    Electron holography microscope with spatial resolution down to.....read more
    Posted by AlexMuller
    Lower cost advanced Nuclear power could dominate future US energy..read more
    Posted by AlexMuller
    Why Hasn’t AI Mastered Language Translation?..read more

Login to your Account

Login to your PlanetTech Account here

Username:
Password:
Remember me
or

Create a New Account

You just need username and password

The following errors occured:
Username:
Email:
Password:
Verify password:
Remember me