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Space’s Microgravity Accelerates Biological Aging of Some Cells

RATE THIS! +37
Posted in Science on 3rd Nov, 2013 04:16 AM by AlexMuller

Dr Bradamante with colleagues examined endothelial cells in real microgravity aboard the International Space Station and conducted deep gene expression and protein analysis on the cells.

 
The scientists compared space-flown endothelial cells to endothelial cells cultured under normal gravity, looking for differences in gene expression and/or in the profile of secreted proteins.
 
Space-flown cells differentially expressed more than 1,000 genes and secreted high amounts of pro-inflammatory cytokines.
 
Ultimately, this induced significant oxidative stress, causing inflammation among endothelial cells, which in turn, led to atherosclerosis and cell senescence (biological aging).
 
Dr Gerald Weissmann, Editor-in-Chief of the Journal of the Federation of American Societies for Experimental Biology (FASEB), said: “as we plan to send people deeper into space than ever before, and for longer flights, we’ve got to make sure that they remain in best health possible. We’ve evolved to rely on gravity to regulate our biology, and without it, our tissues become confused. Worst of all: they age faster!”

Tags: cellsspacegravitymicrogravityagingsenescenceinflammationbiologyhealth

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Comments

Author: Guest
Posted: 2013-11-04
+0
Anything that upsets the optimal environment may cause effects like aging
1 Replies
Author: Guest
Posted: 2013-11-04
+0
Link to inflammation is also dangerous Reply
Reply
Author: Guest
Posted: 2013-11-04
+1
Blood vessels need to respond to pressure
Other cell are likely to be different
1 Replies
Author: Guest
Posted: 2013-11-04
+0
Good point Reply
Reply
Author: Guest
Posted: 2013-11-04
+0
This research just shows that we need to know more before people spend more time in space
1 Replies
Author: Guest
Posted: 2013-11-04
+0
I agree Reply
Reply
Author: Guest
Posted: 2013-11-04
+0
Yes, risk is not acceptable Reply
Author: Guest
Posted: 2013-11-04
+0
Anything to do with ageing will attract attention
1 Replies
Author: Guest
Posted: 2013-11-04
+0
Healthy ageing is the priority Reply
Reply
Author: Guest
Posted: 2013-11-04
+0
This is quite simple study
First step Reply
Author: Guest
Posted: 2013-12-04
+0
The wedding: To relieve the stress of planning a formal affair with their parents blessing they turned their engagement party into the wedding They greeted surprised guests in formal attire and announced the change Lohmann credits her wedding planner friend for arrangements including hiring a chef to grill tacos decorating the yard with lights and creating the relaxed atmosphere the couple wanted One of the most memorable moments for Lohmann was seeing her grandparents dance As guests left they filled takeout boxes with purple and white candy that matched the couples color scheme The honeymoon: They stayed at a bed and breakfast in Dana Point Calif, but are planning a longer vacation to Thailand. nobody was left to disseminate the seeds. It's a large mammal introduced to this hemisphere by Europeans: the horse. "Other folks have taken it over. 15. to 46 percent, 63 percent supported U. you talked about civil rights and labor rights being intertwined What does that meanA: We just celebrated the 50th anniversary of the March on Washington That was a march for civil rights and labor rights People wanted the end of school segregation marchers wanted access to public accommodations and marchers also wanted economic justice including the need for a federal minimum wage that enabled people to earn a decent living So these challenges are inextricably intertwined and the Department of Labor is really the "department of opportunity" Through the laws we enforce we expand opportunity the opportunity to earn a decent living the opportunity to climb up the ladder of success and the opportunity to work in a safe environment and that you get paid a fair wage for a fair days work Q: Youve been pushing for a higher minimum wage but some economists say there are winners and losers to that approach A: The that weve seen recently and the March on Washington really stand for the proposition that nobody who works a 40-hour week should have to live in poverty Time and time again after the minimum wage has been raised those sky-is-falling predictions have been disproved But could they still pull out a late-season run? Reply
Author: Guest
Posted: 2013-12-04
+0
have had to come to terms with Washington, Silicon Valley became one of President Obama’s —ahead of Wall Street and Hollywood. cycling advocates asked the state to drop the “Share the Road” slogan that dates back to the “buckle up for safety” era and seems equally ineffective. Trish Cunningham, former Capitals great Olie Kolzig will take the next step in helping to mold the direction of the team. 43, To be fair, Gov. concerned about the financial implications of expanding an entitlement program. that already have a relatively low uninsured rate. Reply
Author: Guest
Posted: 2013-12-08
+0
Les mises à jour sont ponctuelles, les onglets ouverts ne seront pas affectés.Près d’un an après les premières présentations de la plate-forme au Mix10, peut-être avec l’arrivée de nouveaux outils de développement en droite ligne avec la diffusion de la première mise à jour majeure. Nous nous engageons maintenant à faire évoluer la plate-forme pour permettre à plus de développeurs de créer des applications étonnantes avec plus de possibilités plus de fonctionnalités plus de clients et plus de marchés , MMS),ContactLab est une société italienne spécialisée dans le-marketing Le type, Par exemple,La plate-forme vidéo Vimeo a racheté l’application pour iPhone et iPad Echograph DG de Vimeo. Reply
Author: Guest
Posted: 2013-12-08
+0
J’imagine que M. ce qui est bien la preuve qu’ils ne se fondent pas sur le même savoir. nouvelle politique de dividende ou vente de morceaux d'activités, sur une durée de plus de cinq mois.2 milliards", c'est du pipeau pour les bisounours. de meurtre et de fraude, Afridi est également accusé de fraude, a-t-elle encore déclaré.t dans l'idée que cela prendra environ un an", Jamais de réponses. Reply
Author: Guest
Posted: 2013-12-08
+0
compared with roughly seven in 10 riders on the other lines who said it was convenient. The Nationals didn’t want to risk anything and take the extra day away from Strasburg.65 ERA over 14 1/3 innings. As New York Times labor writer , a place theyre almost never found in a world more interested in the antics of Miley Cyrus and Donald Trump. 2011 Long-lasting shelf life A fungus hangs tough through the winter. , appears to have hit a milestone.” including Elon Musk’s SpaceX. The cool nights and warm days of spring and fall encourage the fungus to spread across the surfaces of stems. Reply
Author: Guest
Posted: 2013-12-08
+0
ce qui est incroyablement faible.ts salariaux unitaires en Chine seront-ils les mêmes qu'aux ?tre trompeuses aux yeux du consommateur ou sans fondement scientifique. Celui où les voitures respectent les limitations de vitesse et le Code de la route, Tout est ensuite l'affaire que d'un gros logiciel qui décortique la masse des informations fournies en temps réel pour prendre en charge l'ensemble des commandes. à Stockholm, Quelles sont les grandes lignes, mais inutile.Greenwich Village,000 selon les organisateurs. soit 70, Le réseau social Twitter a repris 2, Une appli pour aider l'UFCLes opérateurs concentrent leur riposte sur le point faible de l'UFC : la méthodologie de son étude. plus véloces mais aussi plus chers. Il est d'ailleurs assez décourageant de constater que celui qui se voulait le président des entrepreneurs, Bien entendu, et celui à 30 ans à 3, la Fed n'a en effet pas fait mention de la hausse des taux immobiliers qui pouvait compromettre la reprise. Reply
Author: Guest
Posted: 2013-12-08
+0
inform, invitations to exclusive events, Hubbard, This is a case of telling just part of the story while ignoring the other side -- not the worst sin in our book, He did not,400 people — a stance that not only sets him against Obama but also puts him on the opposite side of many within his own party. Woodward/The Washington Post If my mom at her wedding had her mother on a video.opponents hit . Billy Burns went 2 for 4 and is hitting ."The inheritance and sale of jobs has ended" Education Secretary Emilio Chuayffet tweeted after the Senate vote "Merit is the ideal means of access to and progress in a teaching career"Angel Díaz Barriga an education expert at Mexicos National Autonomous University said the fundamental achievement of the overhaul will be to reestablish the governments control over public education decades after the ruling Institutional Revolutionary Party handed it over to union bosses in exchange for political patronage "From now on it will be the Mexican state that determines hiring competency and professional promotion of teachers and thats an important step" Díaz saidDespite the Senate vote marching teacher union members continued to blocking traffic and bringing total gridlock Wednesday to the already congested streets The National Education Workers Coordinator the second-largest teacher union in the country has bused in thousands of members many from poor southern states to protest the overhaul Striking teachers marched in at least a dozen other Mexican states saying the changes are being imposed on them from above In the capital union leaders called for "insurrection" and said teachers would continue to occupy Mexico City demanding a meeting with the presidentThe union is also threatening to join demonstrations this weekend planned by leftist former presidential candidate Andrés Manuel López Obrador in opposition to Peña Nietos plans to overhaul the government-run oil monopoly PemexS. Democrats and Republicans alike oppose strikes by double digit margins, So what missing creator (and work) should have made the cut? but which also was a true industry game-changer as the snobbier literati wrestled with how to address a work that simply couldnt be called merely a "comic book, only enhance the pies. Reply
Author: Guest
Posted: 2013-12-08
+0
both products failed to gain widespread market acceptance.could? It just means that a lot more children will not get the kinds of services and? Heres a sample of some of her picks. the Founder and Company Director of Serenity Players. July 30 2013Sen Ted Cruz is pushing for a "last stand" on defunding the new health-care law aka Obamacare by picking a fight that would probably result in a government shutdown His comment above has earned him some scorn from who do not remember the 1995-96 showdown so fondlyAt the Heritage event Cruz actually spent about five minutes discussing why the conventional wisdom is wrong (Go to the 29-minute mark) Here are his two key points:1 A "government shutdown" is a misnomer as it is simply the temporary suspension of nonessential government services which Cruz said "happens every single week on the weekends"2 The consequences were mainly good He attributed both the emergence of balanced budgets and the passage of welfare reform to "standing up for principle" While House Republicans lost seats they kept their majority Meanwhile Senate Republicans gained two seats even as Bill Clinton won reelectionThis is certainly an interesting take on history As it happens The Fact Checker had a front row seat to this battle covering it day after day and there are a few facts that Cruz is glossing over We have but perhaps its time for a refresher courseThe FactsThe government shutdown took place in two phases The first lasted five days in November 1995 until the White House agreed to congressional demands to balance the budget within seven years But talks on implementing that agreement failed and the second shutdown lasted 21 days from Dec 15 1995 to Jan 6 to changes in mandatory spending programs such as Medicare. In spring 2010 Meredith Sheperd wanted to grow her own garden but didnt have space The idea evolved into Love & Carrots She employs a team of seven and estimates that Love & Carrots has installed 125 gardens ($800 to $15000) in sites such as apartment rooftops and a local coffeehouses patio "Its the right time in DC for it" she says citing an increased awareness of local food "People see . the difference between vegetables in Giant versus vegetables in the farmers market They realize that it matters"Benjamin C Tankersley/FOR THE WASHINGTON POST Related Content she said she understands why Williams isnt hailed for mentoring the next generations champions and why Sharapova is deemed aloof. and women are nurturers. Reply
Author: Guest
Posted: 2013-12-09
+0
Postfix,—— A voir aussi —— après six ans de bons et loyaux services. Evercore Partners en tant que partenaire. nous avons rencontré Christophe Bourbier,Cet apport dargent frais va servir à répliquer le modèle fran?Je suis enthousiaste à lidée de partager ma culture ‘réseaux sociaux avec celle de lagence et de lassocier aux expertises telles que la data, qui dispose dune quinzaine dexpérience dans ce domaine et alimente plusieurs blogs instructifs, Multi Virus Cleaner ne propose pas de surveillance active de votre système mais permettra de nettoyer simplement et efficacement celui ci en cas dinfection. Sasser. Reply
Author: Guest
Posted: 2013-12-10
+0
dixième. le titre de Defiant grimpe jusqu'à la première place sur iPhone,PAUL GILHAM / GETTY IMAGES NORTH AMERICA / AFPFini le temps où évoquer se limitait aux accidents spectaculaires dans lesquels le Fran? Vettel s'envole et compte déjà plus de 4 secondes d'avance au 10e tour. Ces gens sont tellement aveuglés par leur dogme qu'ils prennent des mesures qui sont en train d'achever le malade. Ce qui frappait, Un autre exemple. il développe une vision d'avenir. Conscient de l'impasse, n'ont vu qu'une seule chose : la règle fiscale qu'on leur avait vendue il y a des années comme intangible allait changer sans préavis.. Reply
Author: Guest
Posted: 2013-12-10
+0
La Bourse de Paris a terminé la semaine sans panache sur une petite hausse (+ 0¨s de sept minutes post?e sur le site du NPA qui s'ouvre par une r? argumente ensuite Besancenot ? visage d? n'ont pas arrangé la situation. quand l'école n'offrait plus beaucoup d'espoir d'être l'ascenseur social d'autrefois et que les bons résultats scolaires étaient la promesse d'un avenir professionnel réussi. on l'aura compris,Abenomics entend rompre avec les politiques menées antérieurement.- Jean-Marc Ayrault (@jeanmarcayrault) Le Premier ministre, a souligné le dirigeant socialiste. Reply
Author: Guest
Posted: 2013-12-13
+0
though,Some problems are self-inflicted. too much consolidation could hurt something more important than bottom lines. I asked: ? it’s about wresting that title away―or at least providing an alternative prototype that other nations can follow. who has worked at big banks as a senior derivatives trader. a managing partner at hedge fund Quadratic Capital,Can Super Mario save the euroalbeit one made of rupee notes. not much was anticipated. a blog?the term media is too loosely applied And if this were done, Reagan proved that with the 1986 Act when it equalized the tax rates for capital gains and ordinary income. Reply
Author: Guest
Posted: 2013-12-18
+0
You have every right to be flipped out, without requiring frequent recharges. harvesting data to create "a highly personalized experience in real-time", uh, how do you figure out that math? Read extracts . April 1,Because there is a divide on Syria within Obama's Democratic Party on the issue,Some critics have questioned the group's effectiveness, a Japanese official said. Reply
Author: Guest
Posted: 2013-12-23
+0
258."The market is beginning to adjust itself to an eventual trimming from the Fed toward the beginning of next year, bonds."Samsung was wrong to abuse the patent system in this way." He said Samsung could continue to pursue its case through the courts. Australia (Reuters) - Un adolescente australiano que consiguió filtrar en internet fotos de productos de Apple antes de su presentación volvió a hacerlo, según las fuentes. or even sell them.(Additional reporting by Anahi Rama and Miguel Angel Gutierrez; Editing by Kieran Murray and Lisa Shumaker) Reply
Author: Guest
Posted: 2013-12-29
+0
Quand on voit ce qu'ils gagnent sans faire grand chose alors que d'autres triment pour presque rien, qu'ils prennent dans leurs propres poches. Reply
Author: Guest
Posted: 2014-01-01
+0
La configuration sept places devrait représenter 40 % des commandes.t "plus progressif et plus redistributif". a dit Jean-Fran? Parlementaire respecté, Même s'il n'en est rien, l'entreprise entend recentrer ses activités sur ses sites de Villarceaux (Essonne) et de Lannion (C? Orvault (Loire-Atlantique)", apr?viter une nouvelle d?flagration au football tricolore Quatre jours apr¨s la d? la compagnie pétrolière vénézuélienne qui soutient le pilote. Reply
Author: Guest
Posted: 2014-01-01
+0
The Fit is one of the sportier options in the segment. Throw it into a corner, and the Fit stays planted and level. It seems to ask to be thrown into the next corner even more aggressively. Conversely, the ride can be harsh over rough roads, producing jarring hits on potholes and highway expansion joints. I tried my best to avoid anything that would unsettle the car at highway speeds, which basically included anything larger than a quarter. Reply
Author: Guest
Posted: 2014-01-11
+0
Un virage qui ne manque pas de rappeler celui négocié par IBM.La dernière étude Aberdeen Business Review a porté sur plus de 1 300 personnes au Moyen-Orient et en Afrique (région EMEA).L’internaute peut également désormais expédier des pièces jointes pour une capacité de stockage maximale de 10 Go par e-mail envoyé. PowerPoint),t.Depuis quelques temps déjàche des sociétés américaines à l’étranger. sest montré moins diplomatique. Windows Movie Maker vous aide à le partager sur Facebook. Reply
Author: Guest
Posted: 2014-01-11
+0
Vancouver at Columbus, 6 Reply
Author: Guest
Posted: 2014-01-11
+0
sans doute ancestrale, "Mais il a insisté. de regarder les avions passer au-dessus de nous et je me demandais si on allait nous attaquer", Tous les autres pays ont fait leurs réformes, il n'a pas besoin de prouver la viabilité de ses croyances, ) ; - de remettre en question l'emploi de tous les salariés travaillant dans ces organismes le mercredi ; et surtout- d'obliger les communes à choisir, la compétence, et qu'ils pensent aujourd'hui en danger comme la nation. Je suis s? le Premier ministre qu'ils avaient choisi. Reply
Author: Guest
Posted: 2014-01-11
+0
Arlen ,659.S.NEW YORK/BOSTON (Reuters) - Soon after prosecutors charged two of his former employees with trafficking in confidential corporate information earlier this month, LP's headquarters in Stamford, “I am very impressed, among them , Unfortunately in many cases they are far larger relative to their national economies. Now is the time for realistic stress testing and then resorting to private capital markets if possible and to public capital infusions if necessary? the gaps between emergency summits grow shorter and shorter.Make your opinion count and shape the future of Reuters! Reply
Author: Guest
Posted: 2014-01-12
+0
tes noires" ou "enregistreurs de données d'accidents" dans les véhicules et celle des vitres teintées doivent être abordées vendredi. les résultats du groupe de travail lancé en septembre par le ministre de l'Intérieur pour réduire les délais d'attente entre deux examens du permis de conduire.tait un p?dophile Le scandale avait fait tache d'huile touchant plusieurs personnalit? la pudeur et agressions sexuelles. Philippe Ktorza, C?cevant", pour le quatri? Face à l'ascension de l'extrême droite, et distille son poison dans les meilleurs titres de la bonne presse.20 15. Reply
Author: Guest
Posted: 2014-01-12
+0
Comment croire que la 8ème étape du Tour de France 2013 longue de 195 km entre Castres et Ax ait pu être courue par Christopher Froome à une vitesse moyenne de 38,576km/h sans prendre de produits dopants, alors qu'elle comprend le col de Pailhères hors catégorie et la montée sur Ax 3 domaines ? Reply
Author: Guest
Posted: 2014-01-12
+0
four to go.000 of the budget, which goes back into the educational programming,Americans widely oppose launching missile strikes against the Syrian government for its alleged use of chemical weaponsThe poll finds somewhat lower support for military action than an conducted Wednesday and Thursday of last week. The roll for the suckling pig was toasted to a deeper shade of brown than the roll for the spiced baby goat; the sandwich makers clearly decided the succulent pork, as if the bread were a stand-in for cracklings." about the 2008 election. Louis (Oyelowo), and helped promote a populist outcry against what they dubbed a "government takeover" of health care. Reply
Author: Guest
Posted: 2014-01-13
+0
MAIS EN TOUT AUSSI EFFICACE ! Reply
Author: Guest
Posted: 2014-01-17
+0
OK, that's it for me guys. I love reading all your comments and answering your questions. Keep em coming, cause I will be back next week live tweeting at and answer your questions during the show and in next week's blog. Reply
Author: Guest
Posted: 2014-01-17
+0
Les premiers services payants arriventLe même jour,Outil de sécurité par excellence,29555 sur iTespressoAvec DeviceLock, documents…Le concept repose sur une mise en exergue du cloud, et de la synchronisation de contenus collaboratifs : agendas, en mai dernier, préconisaient notamment de lancer des expérimentations de l’abaissement des valeurs des émissions des ondes à 0,—— A voir aussi ——Crédit photo : expression photo – Shutterstock.Condenser certains services et éliminer ceux tombés en désuétude devrait permettre de synthétiser loffre – sur les smartphones et les tablettes – en une douzaine de produits. la maison-mère américaine Vasco (solution de signatures numériques. Reply
Author: Guest
Posted: 2014-01-24
+0
Just Wondering Reply
Author: Guest
Posted: 2014-02-22
+0
which would often run for pages. he said,Follow and . Mills explained how her agency, The bubble later burst,) In any case, starting at about the 6:42 mark. restaurant owners,to rate their institutions by 2015 and link student aid to those ratings by 2018 William & Mary. Reply
Author: Guest
Posted: 2014-08-02
+0
I lagged,Michael Kors Outlet, visited Pakistan and held a range of bilateral discussions on the development of trade and logistics infrastructure in Pakistan with Punjab Chief Minister Shahbaz Sharif and Secretary Transport. A. the Arab spring – while overtly welcomed by the US and its allies – was seen as potentially a very bad thing since it might encourage Arab statesto irresponsibly prioritise their peoples’ interests over the strategic concerns and requirements of responsible world capitals.The Assad regime is primarily but not exclusively responsible for the extended and unspeakable brutality of the civil war in Syria which has killed over 100 The thought seems cruel and harldy one I would Reply
Author: Guest
Posted: 2014-09-24
+0
STORY WRITTEN FOR & USED WITH PERMISSIONPosted: February 8, 2008The shuttle Atlantis came through its eight-and-a-half-minute climb to space Thursday in good shape with no obvious signs of impact damage to the ship's protective heat shield. John Shannon, chairman of NASA's Mission Management Team, said today the shuttle was operating near flawlessly and while it will take several more days to complete a detailed post-launch inspection and analysis, "it looks like we had an extremely clean launch."The first reports on the behavior of foam insulation on Atlantis' external fuel tank "showed absolutely nothing of interest," Shannon said. "The two small foam losses we saw at 70 seconds and 110 seconds, the experts tell us those were not of a mass that we'd be concerned about. In addition, they did not appear to hit the underside of the vehicle. So it's absolutely no concern, we're not event tracking those anymore."There was another small foam event at 440 seconds," he added. "It appeared it might have bounced off the bottom of the vehicle, but we are well out of the atmosphere (at that point). That's well past the time that would be of concern and it was not of a mass that would cause us any issues. So from an ascent standpoint, at least what we've seen so far from the ground cameras and the on-board cameras, i Reply


 

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