Social Media Sidebar

Announcement

Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

People say we're running out of energy. That's only true if we stick with these old 19th century technologies. We are awash in energy from sunlight.

 

Ray Kurzweil

 

Study Finds Alcohol Creates Effects of Fast-Acting Antidepressant

RATE THIS! +46
Posted in Science on 6th Oct, 2016 08:41 AM by AlexMuller

The connection between alcohol abuse and depression has been noted for years. A new study plots out that biochemical path, using mouse models to show that alcohol produces the same effect seen in newer rapid-acting antidepressants, such as ketamine, which bring lasting relief in hours.

 

The effects of alcohol on depression take effect quickly and can last up to 24 hours, the study found. For years, one of the challenges in treating depression has been the fact that many therapies take up to 2 weeks to build up in a patient’s system before there is a noticeable effect; this can lead some patients to believe the drugs don’t work, or patients can continue to suffer severe symptoms while waiting for relief.

 

For patients trying to stop alcohol abuse, it’s especially difficult if the substance is providing the only respite from symptoms, and there is a gap before relief from pharmacotherapy occurs. In working with the mouse models, researchers examined how alcohol behaved on the same molecular pathway that is activated by rapid antidepressants, according to lead author Kimberly Raab-Graham, PhD, associate professor of physiology and pharmacology at Wake Forest School of Medicine.

 

Ethanol created the same receptor response as the rapid antidepressants, an alteration of GABABR expression and signaling. Further work showed the effect that alcohol has on fragile-X mental retardation protein, or FMRP, as shown by experiments with “knockout” mice who were missing the protein. Thus, this protein was confirmed as a key regulator for the antidepressant effect of acute ethanol exposure. The researchers wrote that the presence of major depression doubles the risk of alcohol use, and the reverse is also true.

 

While more work is needed, the findings offer a biological reason “for the natural human instinct to self-medicate,” Raab-Graham said. “They also define a molecular mechanism that may be a critical contributor to the comorbidity that occurs with alcohol use disorder and major depressive disorder.”


Tags: brainneurosciencehealthmedicinebiologyalcoholdepression

Read original article » Back to category

Comments

Author: Guest
Posted: 2016-10-07
+1
This is very interesting - finding out molecular bases between ethanol effects and ketamine could provide new ideas for fast acting antidepressants that could be taken daily without addiction
1 Replies
Author: Guest
Posted: 2016-10-07
+0
For ethanol, it is important to note that while it can be a fast acting antidepressant in long term use could be one of the factors that contributes to depression Reply
Reply


 

Recent headlines

  • Posted in Business on 2017-09-21 08:16:42
    Google signs $1.1bn HTC smartphone deal..read more
    Posted in Business on 2017-09-21 08:11:40
    US solar plant costs fall another 30 per cent in just one.....read more
    Posted in Science on 2017-09-21 08:04:25
    SpaceX will call global internet satellite network Starlink..read more
    Posted in Software on 2017-09-20 19:05:15
    Google boosts Cloud Natural Language API with automatic.....read more
    Posted in Software on 2017-09-20 18:55:34
    Salesforce to launch $50 million artificial intelligence.....read more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in about.....read more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for commercial.....read more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 Downloads..read more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into new.....read more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs,.....read more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for commercial.....read more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short Sighted..read more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, but.....read more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in about.....read more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target mitochondria..read more

Recent Blog Posts

  • Posted by AlexMuller
    Scientists probe Neptune's depths to reveal secrets of icy.....read more
    Posted by AlexMuller
    New terahertz imaging approach could speed up skin cancer.....read more
    Posted by AlexMuller
    Rebutting the claim that antidepressants do not work..read more
    Posted by AlexMuller
    Artificial neural networks decode brain activity during.....read more
    Posted by AlexMuller
    Four Earth-sized planets detected orbiting the nearest.....read more

Login to your Account

Login to your PlanetTech Account here

Username:
Password:
Remember me
or

Create a New Account

You just need username and password

The following errors occured:
Username:
Email:
Password:
Verify password:
Remember me