Social Media Sidebar

Announcement

Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

When seen through the lens of technology, few resources are truly scarce; they’re mainly inaccessible. 

 

Peter Diamandis

Targeting Multiple Myeloma With Coated And Loaded Nanoparticles

RATE THIS! +36
Posted in Science on 11th Jul, 2014 01:39 AM by AlexMuller

Bioengineers, physicians and scientists working together at the Dana-Farber Cancer Institute have created, using molecular biology and biochemical engineering, a nanoparticle that simultaneously attacks bone cancer and strengthens bone damaged by cancer.

 

The nanoparticle reduces the tumor volume, increases bone, and most importantly, significantly extends the survival time of a model animal with multiple myeloma, a type of bone cancer. The nanoparticle was engineered to play the dual role of targeting and killing cancerous cells in bone, as well as regenerating material lost due to the deterioration caused by the cancer’s influence on the bone environment. Because cancer drugs generally flood the body even hitting tissues that are healthy (though ostensibly with a weaker effect than against diseased tissue), they have strong, negative side effects.  Proper targeting the right tissues will alleviate the severity of some of these toxic side effects.

 
The nanoparticle was tested on a mouse with multiple myeloma, a cancer of the bone in which plasma cells proliferate wildly.  Plasma cells are chemical factories, producing antibodies that assist in immune response, but also releasing chemical messages to nearby cells.  In multiple myeloma, a genetic defect causes plasma cells to proliferate and accumulate.  Moreover, the plasma cells produce excessive amounts of antibody protein that poisons the organism, and sends incorrect chemical signals that result in bone tissue death and degradation.
 
The scientists optimized the type of material used to make the nanoparticles so as to maximize circulation in blood and targeting to bone.  The targeting was accomplished by coating the nanoparticle with alendronate (sold as Fosamax), a well-known medical molecule that binds to the bone matrix.  In this way the nanoparticle is targeted to the bone tissue.  The nanoparticle was then loaded with a special anti-cancer drug bortezomib (sold as Velcade) which shuts down the waste disposal system of the cancer cells.
 
Cancer cells are particularly sensitive as they produce many byproducts that need to go through the waste system.  When the waste system is shut down, cancer cells are particularly vulnerable and become clogged with excess material.  The drug is slowly released from the interior of the nanoparticle.  Because the targeting system should bring it quickly to the bone, most of the drug will be released at the correct location.

Tags: cancerbonenanotechnologymedicinenanoparticle

Read original article » Back to category

Comments



 

Recent headlines

  • Posted in Software on 2017-11-20 17:24:02
    The 3 biggest threats to your Bitcoin (and 10 tips to.....read more
    Posted in Medicine on 2017-11-20 17:20:08
    How to open the blood-brain-barrier with precision for.....read more
    Posted in Hardware on 2017-11-20 17:05:43
    China on Pace for Record Solar-Power Installations..read more
    Posted in Science on 2017-11-20 00:42:21
    Small steps forward as UN climate talks end in Bonn..read more
    Posted in Hardware on 2017-11-20 00:37:56
    US gov should support SpaceX and develop moon bases..read more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in about.....read more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for commercial.....read more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 Downloads..read more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into new.....read more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs,.....read more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for commercial.....read more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short Sighted..read more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, but.....read more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in about.....read more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target mitochondria..read more

Recent Blog Posts

  • Posted by AlexMuller
    Martian landscapes formed from sand 'levitating' on a little.....read more
    Posted by AlexMuller
    Scientists detect comets outside our solar system..read more
    Posted by AlexMuller
    Advanced artificial limbs mapped in the brain..read more
    Posted by AlexMuller
    Bacteria have a sense of touch..read more
    Posted by AlexMuller
    Recurrent brain cancer: New hope with phase 1 clinical trial.....read more

Login to your Account

Login to your PlanetTech Account here

Username:
Password:
Remember me
or

Create a New Account

You just need username and password

The following errors occured:
Username:
Email:
Password:
Verify password:
Remember me