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Tibetan altitude gene inherited 'from extinct species'

RATE THIS! +34
Posted in Science on 3rd Jul, 2014 06:52 PM by AlexMuller

A gene that allows present-day people to cope with life at high altitude was inherited from an extinct species of human, Nature journal has reported. The variant of the EPAS-1 gene, which affects blood oxygen, is common in Tibetans, many of whom live at altitudes of 4,000m all year round. But the DNA sequence matches one found in the extinct Denisovan people.

 

 Many of us carry DNA from extinct humans who interbred with our ancestors as the latter expanded out of Africa. Both the Neanderthals, who emerged around 400,000 years ago and lived in Europe and western Asia until 35,000 years ago - and the enigmatic Denisovans contributed DNA to present-day people.

 
The Denisovans are known only from DNA extracted from the finger bone of a girl unearthed at a cave in central Siberia. This 40,000-50,000-year-old bone fragment, as well as a rather large tooth from another individual, are all that is known of this species. The tiny "pinky" bone yielded an entire genome sequence, allowing scientists to compare it to the genetic sequences of modern people in order to better understand the legacy of ancient interbreeding.
 
Now, researchers have linked an unusual variant of the EPAS1 gene, which is involved in regulating the body's production of haemoglobin, the molecule that carries oxygen in the blood - to the Denisovans. When the body is exposed to the low oxygen levels encountered at high elevations, EPAS1 tells other genes in the body to become active, stimulating a response that includes the production of extra red blood cells.

Tags: genegeneticshumansDNAoxygen

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Comments

Author: Guest
Posted: 2014-07-04
+1
Being able to analyse DNA from the bones of our ancestors and other animals is providing many new insights into evolution. This is a great example- finding genes that provide selective advantage and explain how they work! Great article! Reply


 

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