Social Media Sidebar

Announcement

Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

People say we're running out of energy. That's only true if we stick with these old 19th century technologies. We are awash in energy from sunlight.

 

Ray Kurzweil

 

University of California scientists create malaria-blocking mosquitoes

RATE THIS! +54
Posted in Science on 27th Nov, 2015 02:00 AM by AlexMuller

Irvine, Calif, Using a groundbreaking gene editing technique, University of California scientists have created a strain of mosquitoes capable of rapidly introducing malaria-blocking genes into a mosquito population through its progeny, ultimately eliminating the insects' ability to transmit the disease to humans.

 
This new model represents a notable advance in the effort to establish an antimalarial mosquito population, which with further development could help eradicate a disease that sickens millions worldwide each year.
 
To create this breed, researchers at the Irvine and San Diego campuses inserted a DNA element into the germ line of Anopheles stephensi mosquitoes that resulted in the gene preventing malaria transmission being passed on to an astonishing 99.5 percent of offspring. A. stephensi is a leading malaria vector in Asia.
 
The study underlines the growing utility of the Crispr method, a powerful gene editing tool that allows access to a cell's nucleus to snip DNA to either replace mutated genes or insert new ones. Results appear this week in the early online edition of Proceedings of the National Academy of Sciences.
 
"This opens up the real promise that this technique can be adapted for eliminating malaria," said Anthony James, Distinguished Professor of molecular biology & biochemistry and microbiology & molecular genetics at UCI.
 
For nearly 20 years, the James lab has focused on engineering anti-disease mosquitoes. His anti-dengue fever models have been tested in cage trials in Mexico, and in 2012, he helped show that antibodies that impair the parasite's biology adapted from the immune systems of mice can be introduced into mosquitoes. This trait, though, could only be inherited by about half of the progeny.
 
Earlier this year, UC San Diego biologists Ethan Bier and Valentino Gantz working with fruit flies announced the development of a new method for generating mutations in both copies of a gene. This mutagenic chain reaction involved using the Crispr-associated Cas9 nuclease enzyme and allowed for transmission of mutations through the germ line with an inheritance rate of 95 percent.
 
The two groups collaborated to fuse Bier and Gantz's method with James' mosquitoes. Gantz packaged antimalaria genes with a Cas9 enzyme (which can cut DNA) and a guide RNA to create a genetic 'cassette' that, when injected into a mosquito embryo, targeted a highly specific spot on the germ line DNA to insert the antimalaria antibody genes.
 
To ensure that the element carrying the malaria-blocking antibodies had reached the desired DNA site, the researchers included in the cassette a protein that gave the progeny red fluorescence in the eyes. Almost 100 percent of offspring -- 99.5 percent, to be exact -- exhibited this trait, which James said is an amazing result for such a system that can change inheritable traits.
 
He added that further testing will be needed to confirm the efficacy of the antibodies and that this could eventually lead to field studies. "This is a significant first step," said James, a National Academy of Sciences member. "We know the gene works. The mosquitoes we created are not the final brand, but we know this technology allows us to efficiently create large populations."

Tags: malariaparasitehealthmedicineresearchdiseasebiology

Read original article » Back to category

Comments

Author: Guest
Posted: 2015-11-27
+1
An amazing result achieved by gene editing! Helpfully further testing will confirm this initial excitement and these insects with anti-malaria antibodies will be effective Reply
Author: Guest
Posted: 2015-11-27
+0
We will see more and more gene editing implemented to create new verities of species and also importantly to change disease genes when this could lead to cure Reply


 

Recent headlines

  • Posted in Software on 2017-09-19 18:06:17
    China orders Bitcoin exchanges in capital city to close..read more
    Posted in Hardware on 2017-09-19 18:00:15
    LinkSpace is a Chinese startup that will try to make.....read more
    Posted in Medicine on 2017-09-19 17:54:24
    A Permanent Vaccine Against Tooth Cavity and Decay..read more
    Posted in Software on 2017-09-18 18:14:00
    China to become artificial intelligence 'world leader' by.....read more
    Posted in Science on 2017-09-18 18:10:24
    There's an Ocean Deep Inside the Earth..read more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in about.....read more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for commercial.....read more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 Downloads..read more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into new.....read more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs,.....read more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for commercial.....read more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short Sighted..read more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, but.....read more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in about.....read more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target mitochondria..read more

Recent Blog Posts

  • Posted by AlexMuller
    Scientists probe Neptune's depths to reveal secrets of icy.....read more
    Posted by AlexMuller
    New terahertz imaging approach could speed up skin cancer.....read more
    Posted by AlexMuller
    Rebutting the claim that antidepressants do not work..read more
    Posted by AlexMuller
    Artificial neural networks decode brain activity during.....read more
    Posted by AlexMuller
    Four Earth-sized planets detected orbiting the nearest.....read more

Login to your Account

Login to your PlanetTech Account here

Username:
Password:
Remember me
or

Create a New Account

You just need username and password

The following errors occured:
Username:
Email:
Password:
Verify password:
Remember me