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Whole-genome sequences of 17 of the world’s oldest living people published

RATE THIS! +28
Posted in Science on 13th Nov, 2014 09:30 PM by AlexMuller

Using 17 genomes, researchers were unable to find rare protein-altering variants significantly associated with extreme longevity, according to a study published November 12, in the open-access journal PLOS ONE by Hinco Gierman from Stanford University.

 
Supercentenarians are the world’s oldest people, living beyond 110 years of age. Seventy-four are alive worldwide; 22 live in the U.S. The authors of this study performed whole-genome sequencing on 17 supercentenarians to explore the genetic basis underlying extreme human longevity.
 
From this small sample size, the researchers were unable to find rare protein-altering variants significantly associated with extreme longevity compared to control genomes. However, they did find that one supercentenarian carries a variant associated with a heart condition, which had little or no effect on his/her health, as this person lived over 110 years.
 
Although the authors didn’t find significant association with extreme longevity, the authors have publicly published the genomes, making them available as a resource for future studies on the genetic basis of extreme longevity.

Tags: agingbiologyhealthmedicinediseaselifespangeneticsgenome

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Comments

Author: Guest
Posted: 2014-11-14
+1
Complexity of ageing is unlikely to be accessed just by studying genes in a relatively small sample but making these data public is a good contribution to further research Reply


 

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