Blood Factors Halve the Epigenetic Age in Mice Cells

Young blood plasma is known to confer beneficial effects on various organs in mice. However, it was not known whether young plasma rejuvenates cells and tissues at the epigenetic level; whether it alters the epigenetic clock, which is a highly-accurate molecular biomarker of aging.

Researchers developed and validated six different epigenetic clocks for rat tissues that are based on DNA methylation. They demonstrated that a plasma-derived treatment markedly reverses aging according to epigenetic clocks and benchmark biomarkers of aging. According to the six epigenetic clocks, the plasma fraction treatment rejuvenated liver by 73.4% (ranging from 63% to 81% depending on the clock), blood by 52% (ranging from 47 to 56%), heart by 52% (ranging from 40 to 74%), and hypothalamus by 11% (ranging from 1 to 20%). The rejuvenation effects are even more pronounced if we use the final versions of our epigenetic clocks: liver 75%, blood 66%, heart 57%, hypothalamus 19%. According to the final version of the epigenetic clocks, the average rejuvenation across four tissues was 54.2%.