Mount Sinai researchers conducting clinical trials of a drug targeting a cancer gene found that it increased metastatic cancer patients’ survival and was able to work within the brain, according to a study published in Clinical Cancer Research in February.
The drug entrectinib targets cancers that involve fusions between the cancer gene NTRK and other genes, including certain types of lung, breast, colon, and other cancers. This study looked into the effectiveness of the drug a year after three clinical trials were completed and found patients’ response rates post-trial were 60 percent.
A significant finding in this study, which was not seen in the initial trials, was that the drug is able to cross the blood-brain barrier effectively. Researchers found evidence that the therapy was working against metastatic cancer that spread to the brain.
“This is the largest study evaluating the safety and activity of entrectinib in NTRK fusion-positive solid tumors. The confirmation of substantial effect on metastases in the brain suggests that entrectinib could address the unmet need of an effective treatment for patients with NTRK fusion-positive tumors that spread to the central nervous system. Although NTRK fusions are rare, our results should encourage broader screening for these fusions in patients with solid tumors as they may benefit from entrectinib, particularly because the extended life expectancy of these patients may increase the likelihood of metastases in the brain.”