Further to a list of side effects ranging from mildly unpleasant to just plain awful, the scattergun nature of chemotherapy often sees healthy tissue damaged along with the cancerous cells. Attacking these cancer cells with better precision would lead to more effective treatments and reduce harmful side effects, and has been a primary objective for researchers.
Among this group is a team of scientists that has developed a way of administering cancer-fighting chemicals using an electric field that is claimed to enable a highly-targeted form of treatment. "A big challenge with many drugs is getting them where they need to go," says Lissett Bickford, an assistant professor in the Department of Biomedical Engineering at Virginia Tech, one of the study’s co-authors. "This technology basically forces drugs directly to and through the tumor, allowing all cancer cells in the treatment zone to get that exposure."
The technique, known as iontophoresis, involves a small device containing a reservoir of chemotherapy drugs that can be either implanted in the tumor or placed on the skin to create the electric field. In testing, mice suffering from human inflammatory breast cancer were treated with the iontophoresis method in addition to regular intravenous chemotherapy and experienced increased survival times compared with either treatment being administered on its own. Bringing radiation therapy into the mix served to boost this even further.
Also of note was that treating mice with iontophoresis after they had already been treated with intravenous chemotherapy served to boost the concentration of the drug in the tumor, while only bringing about a negligible difference in concentration in the blood plasma. Doing so could reduce common side effects of chemotherapy, which include everything from fatigue, to hair loss to nausea and vomiting.